| Project/Area Number |
15K19115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 日本脳炎ウイルス / ゲノム環状化 / 相補性 / 複製 / RNA / RNA複製 / ウイルスタンパク翻訳 |
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| Outline of Final Research Achievements |
Functional analyzes of four pairs of complement sequences found in Japanese encephalitis virus (JEV) genome terminus were conducted to elucidate the effect of the genome circularization on virus replication. As results, essential sequences and/or complementarity for genome circularization as well as virus replication were determined. These regions possessed identical functions both in mammalian cells and mosquito cells. The essential sequences and/or complementarity for genome circularization were all important for virus replication. On the other hand, the essential sequences and/or complementarity for virus replication were not always essential for genome circularization. Since functions of these regions of JEV genome have been largely unknown, findings obtained in the present study can contribute to the novel anti JEV drug development which has not been available yet.
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