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Induction of vaccine-elicited T cell responses by non-natural amino acids

Research Project

Project/Area Number 15K19116
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionKyushu University (2016)
Kinki University (2015)

Principal Investigator

Motozono Chihiro  九州大学, 医学研究院, 助教 (10642910)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsT細胞 / ウイルス感染 / ペプチド免疫 / ペプチドワクチン / レトロウイルス
Outline of Final Research Achievements

Understanding functional characteristics of T-cell responses associated with effective elimination of pathogenic retroviruses or tumors is crucial for the development of vaccines. In this study, we demonstrated that the use of an appropriate epitope preferentially induces functional T cell responses in the early phase of acute retroviral infection that contribute to the effective antiviral protection, providing a better information for the development of vaccine.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 Other

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Book (3 results) Remarks (1 results) Funded Workshop (1 results)

  • [Journal Article] Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.2016

    • Author(s)
      Takamura, S., H. Yagi, Y. Hakata, C. Motozono, S. R. McMaster, T. Masumoto, M. Fujisawa, T. Chikaishi, J. Komeda, J. Itoh, M. Umemura, A. Kyusai, M. Tomura, T. Nakayama, D. L. Woodland, J. E. Kohlmeier, and M. Miyazawa
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 213 Issue: 13 Pages: 3057-3073

    • DOI

      10.1084/jem.20160938

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Distortion of the MHC class I binding groove to accommodate an insulin-derived 10-mer peptide2015

    • Author(s)
      Chihiro Motozono, James A. Pearson, Evy De Leenheer, Pierre J. Rizkallah, Konrad Beck, Andrew Trimby, Andrew K. Sewell, F. Susan Wong and David K. Cole
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Pages: 18924-18933

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clonotypically similar hybrid αβ TCRs can exhibit markedly different surface expression, antigen specificity and cross-reactivity2015

    • Author(s)
      Chihiro Motozono, John S Bridgeman, David A Price, Andrew K. Sewell and Takamasa Ueno
    • Journal Title

      Clinical & Experimental Immunology

      Volume: 180 Pages: 560-570

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Vaccine-elicited preferential induction of polyfunctional Th cells is associated with protection against acute retroviral infection2016

    • Author(s)
      C. Motozono, S. Tsuji-Kawahara, S. Takamura, M. Miyazawa
    • Organizer
      International congress of Immunolgy
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Vaccine-elicited preferential induction of germinal center follicular helper T cells is associated with protection against retroviral infection2015

    • Author(s)
      Chihiro Motozono, Sachiyo Tsuji-Kawahara, Shiki Takamura, Hideo Yagita, M. Miyazawa
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター (札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] B cell-intrinsic TLR7 signaling is required to prevent the generation of recombinant viruses following retrovirus infection2015

    • Author(s)
      Tsuji-Kawahara Sachiyo, Kawasaki Yuri, Motozono Chihiro, Takamura Shiki, Miyazawa Masaaki
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター (札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017

    • Author(s)
      上地貴音、本園千尋
    • Total Pages
      355
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Annual Research Report
  • [Book] 臨床免疫・アレルギー科2016

    • Author(s)
      今井崇史、高野智嗣、本園千尋、山崎晶
    • Total Pages
      200
    • Publisher
      科学評論社
    • Related Report
      2016 Annual Research Report
  • [Book] THE LUNG perspectives2016

    • Author(s)
      鳥越祥太, 本園千尋, 山﨑晶
    • Total Pages
      120
    • Publisher
      メディカルレビュー社
    • Related Report
      2016 Annual Research Report
  • [Remarks] 近畿大学医学部免疫学教室

    • URL

      http://www.med.kindai.ac.jp/immuno/

    • Related Report
      2015 Research-status Report
  • [Funded Workshop] International congress of Immunolgy2016

    • Place of Presentation
      Melbourne (Australia)
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2020-01-20  

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