Identification of host factors associated with persistent transactivation of HIV
Project/Area Number |
15K19117
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Virology
|
Research Institution | Microbial Chemistry Research Foundation |
Principal Investigator |
ISHIZAKA Aya 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員 (70746859)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | HIV / 残存感染細胞 / 免疫活性化 / 潜伏感染 |
Outline of Final Research Achievements |
In this study, we identified prematurely terminated short HIV-1 transcripts (STs) in peripheral blood mononuclear cells as an efficient intracellular biomarker to monitor viral activation and immune status in patients with cART-mediated full viral suppression in plasma. The levels of STs strongly reflected chronic immune activation. These observations represent evidence for a relationship between viral persistence and host immune activation, which in turn results in the suboptimal increase in CD4+ cells despite suppressive antiretroviral therapy. This cell-based measurement of viral persistence contributes to an improved understanding of the dynamics of viral persistence in patients.
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Report
(3 results)
Research Products
(8 results)