| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We established methodology of analysis of proviral genomes from sorted multiple cell subsets derived from Macaque tissues. By the analysis of proviral genomes in tissues in an SIV controller, number of CTL escape mutations in CD4+ cells in Lymph node cells and in Rectal tissues tended to be higher than in PBMCs. In another animal, proviral genomes in the specific tissues were distinct from viral genomes derived from plasma. These data suggest existence of independent environment of SIV latent infection in SIV infected animals. This study elucidated a part of dynamics of provirus in SIV infected rhesus macaque.
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