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Analysis of latent reservoir in SIV controlles

Research Project

Project/Area Number 15K19119
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionKumamoto University (2016-2017)
National Institute of Infectious Diseases (2015)

Principal Investigator

Nomura Takushi  熊本大学, エイズ学研究センター, 特定事業研究員 (80711001)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsSIV / Latent Reservoir / CTL / 逃避変異 / プロウイルス / 複製制御
Outline of Final Research Achievements

We established methodology of analysis of proviral genomes from sorted multiple cell subsets derived from Macaque tissues. By the analysis of proviral genomes in tissues in an SIV controller, number of CTL escape mutations in CD4+ cells in Lymph node cells and in Rectal tissues tended to be higher than in PBMCs. In another animal, proviral genomes in the specific tissues were distinct from viral genomes derived from plasma. These data suggest existence of independent environment of SIV latent infection in SIV infected animals. This study elucidated a part of dynamics of provirus in SIV infected rhesus macaque.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015 Other

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts2017

    • Author(s)
      Seki Sayuri、Nomura Takushi、Nishizawa Masako、Yamamoto Hiroyuki、Ishii Hiroshi、Matsuoka Saori、Shiino Teiichiro、Sato Hironori、Mizuta Kazuta、Sakawaki Hiromi、Miura Tomoyuki、Naruse Taeko K.、Kimura Akinori、Matano Tetsuro
    • Journal Title

      PLOS Pathogens

      Volume: 13 Issue: 9 Pages: e1006638-e1006638

    • DOI

      10.1371/journal.ppat.1006638

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Augmentation of anti-simian immunodeficiency virus activity in CD8+ cells by neutralizing but not nonneutralizing antibodies in the acute phase2016

    • Author(s)
      Yamamoto H, Iseda S, Nakane T, Nomura T, Takahashi N, Seki S, Nakamura M, Ishii H and Matano T
    • Journal Title

      AIDS

      Volume: 30(15) Issue: 15 Pages: 2391-4

    • DOI

      10.1097/qad.0000000000001221

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8+ T-cell frequencies in a macaque AIDS model2016

    • Author(s)
      Ishii H, Matsuoka S, Nomura T, Nakamura M, Shiino T, Sato Y, Iwata-Yoshikawa N, Hasegawa H, Mizuta K, Sakawaki H, Miura T, Koyanagi Y, Naruse TK, Kimura A, Matano T
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 30153-30153

    • DOI

      10.1038/srep30153

    • NAID

      120006346255

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Biphasic CD8+ T-cell defense in elite SIV control by acute-phase passive neutralizing antibody immunization2016

    • Author(s)
      Iseda S, Takahashi N, Poplimont H, Nomura T, Seki S, Nakane T, Nakamura M, Shi S, Ishii H, Furukawa S, Harada S, Naruse TK, Kimura A, Matano T, Yamamoto H
    • Journal Title

      J Virol

      Volume: 90 Issue: 14 Pages: 6276-6290

    • DOI

      10.1128/jvi.00557-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers2015

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto, Hiroshi Ishii, Hirofumi Akari, Taeko K. Naruse, Akinori Kimura, Tetsuro Matano
    • Journal Title

      PLOS Pathogens

      Volume: 11 Issue: 11 Pages: e1005247-e1005247

    • DOI

      10.1371/journal.ppat.1005247

    • NAID

      120005763387

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Induction of mutant epitope-specific CD8+ T cells is an indicator of the beginning of viral control failure in SIV controllers.2017

    • Author(s)
      Takushi Nomura, Hiroshi Ishii, Sayuri Seki, Hiroyuki Yamamoto, Kazutaka Terahara, Tomoyuki Miura and Tetsuro Matano
    • Organizer
      35th Annual symposium on nonhuman primate models for AIDS
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of wild-type and mutant epitope-specific CD8+ T cell responses in SIV controllers.2017

    • Author(s)
      Takushi Nomura, Hiroshi Ishii, Sayuri Seki, Hiroyuki Yamamoto, Kazutaka Terahara, Tomoyuki Miura and Tetsuro Matano
    • Organizer
      65th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2017 Annual Research Report
  • [Presentation] SIV複製制御個体におけるSIV野生型/変異型エピトープ特異的CTL誘導動態の解析2017

    • Author(s)
      野村拓志、石井洋、関紗由里、山本浩之、寺原和孝、三浦智行、俣野哲朗
    • Organizer
      第31回日本エイズ学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of proviral genome sequences in multiple cell subsets in SIV-infected rhesus macaques2016

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto, Kazutaka Terahara, Sayuri Seki and Tetsuro Matano
    • Organizer
      17th Kumamoto AIDS seminar
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2016-10-31
    • Related Report
      2016 Research-status Report
  • [Presentation] Proviral genome sequences in lymph nodes and bone marrows in SIV-infected rhesus macaques2016

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto, Kazutaka Terahara, Sayuri Seki and Tetsuro Matano
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Analysis of proviral genome sequences in individual cell subsets in SIV-infected rhesus macaques2016

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto, Kazutaka Terahara, Sayuri Seki and Tetsuro Matano
    • Organizer
      34th Annual Symposium on Nonhuman Primate
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-10-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of IL-7 and IL-15 administration on SIV controllers2015

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto, and Tetsuro Matano
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
  • [Book] 実験医学 別冊 2016 Vol.34 No.132016

    • Author(s)
      野村拓志、俣野哲朗
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2016 Research-status Report
  • [Remarks] 国立感染症研究所エイズ研究センター Publications

    • URL

      http://square.umin.ac.jp/arc/Matano_Research_Group_JP/Publications.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] Matano Research Group(俣野研究グループ) Publications

    • URL

      http://square.umin.ac.jp/arc/Matano_Research_Group_JP/Publications.html

    • Related Report
      2016 Research-status Report 2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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