Analysis of latent reservoir in SIV controlles
| Project/Area Number |
15K19119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kumamoto University (2016-2017)
National Institute of Infectious Diseases (2015) |
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Principal Investigator |
Nomura Takushi 熊本大学, エイズ学研究センター, 特定事業研究員 (80711001)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | SIV / Latent Reservoir / CTL / 逃避変異 / プロウイルス / 複製制御 |
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| Outline of Final Research Achievements |
We established methodology of analysis of proviral genomes from sorted multiple cell subsets derived from Macaque tissues. By the analysis of proviral genomes in tissues in an SIV controller, number of CTL escape mutations in CD4+ cells in Lymph node cells and in Rectal tissues tended to be higher than in PBMCs. In another animal, proviral genomes in the specific tissues were distinct from viral genomes derived from plasma. These data suggest existence of independent environment of SIV latent infection in SIV infected animals. This study elucidated a part of dynamics of provirus in SIV infected rhesus macaque.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8+ T-cell frequencies in a macaque AIDS model2016
Author(s)
Ishii H, Matsuoka S, Nomura T, Nakamura M, Shiino T, Sato Y, Iwata-Yoshikawa N, Hasegawa H, Mizuta K, Sakawaki H, Miura T, Koyanagi Y, Naruse TK, Kimura A, Matano T
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 30153-30153
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Biphasic CD8+ T-cell defense in elite SIV control by acute-phase passive neutralizing antibody immunization2016
Author(s)
Iseda S, Takahashi N, Poplimont H, Nomura T, Seki S, Nakane T, Nakamura M, Shi S, Ishii H, Furukawa S, Harada S, Naruse TK, Kimura A, Matano T, Yamamoto H
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Journal Title
J Virol
Volume: 90
Issue: 14
Pages: 6276-6290
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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