Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
Hepatitis B virus (HBV) antigens are involved in the suppression of the immune response to the virus. HBs antigens in cells infected with genotype A (Gt-A) virus were more abundantly expressed than those in cells infected with genotype C (Gt-C) virus. In the present study, transcription and translation efficiency were examined to analyze the regulatory mechanisms of HBs antigen expression. The results revealed that the transcription activities of the S1 and S2 promoters derived from Gt-A and Gt-C are comparable. In addition, no significant difference was observed in translation efficiency. These results suggest that HBs antigen expression is regulated after translation.
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