Regulation of antigen-specific immune responses by stoichiometric activated individual CD4 T cells
| Project/Area Number |
15K19128
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Tokyo Medical University (2016-2017)
Osaka University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 獲得免疫 / 一細胞操作 / カルシウムイメージング / T細胞 / 1細胞操作 / 蛍光イメージング / 抗原特異性 / 単一細胞操作 / ライブセルイメージング / 数理モデル / 制御性Ｔ細胞 |
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| Outline of Final Research Achievements |
Adaptive immunity is involved in the specific antigen recognition between T lymphocytes (T cells) and antigen presenting cells (APCs). It has been believed that T cells show antigen-specific response even at single cell level. In this study, using single cell manipulation and live cell imaging, we developed a single cell assay system that can monitor T cell activation by T cell-APC interaction. We found that the responsibility and the antigen-specificity of T cells were quite poor. When APCs interact with activated T cells, the antigen-specificity of T cells were increases. On the other hand, interaction with regulatory T cells that function inhibitory in T cell response did not enhance T cell response. We suggest that, for T cells, to sense the surrounding condition of APCs is essential for antigen-specific immune responses.
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Report
(4 results)
Research Products
(9 results)
