Research Project
Grant-in-Aid for Young Scientists (B)
T-follicular regulatory T-cells (Tfr) have a critical role for controlling antibody responses by germinal center B-cells. I have discovered that Tfr can differentiate into a mature germinal center resident subset characterised by a lack of expression of the high affinity IL-2 receptor, CD25. This allows the cells to upregulate the IL-2 inhibited transcription factor BCL-6 and travel to the germinal center to suppress B-cells. These cells can be found in both mice and humans and unlike most regulatory T-cells (Tregs), of which Tfr are a subgroup, are inhibited by the presence of IL-2. This demonstrates a fundamental split in regulatory T-cells into IL-2 dependent Tregs and IL-2 independent Tfr and has important implications for many clinical trials using IL-2 to control Treg function.
All 2017 2016 2015
All Journal Article (4 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 4 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results, Invited: 1 results) Book (2 results)
Cell Reports
Volume: 18 Issue: 8 Pages: 906-916
10.1016/j.celrep.2017.01.067
PLOS one
Volume: 11 Issue: 9 Pages: e0162306-e0162306
10.1371/journal.pone.0162306
Stem Cells Dev
Volume: 25 Issue: 10 Pages: 774-87
10.1089/scd.2016.0009
Science
Volume: 349 Issue: 6251 Pages: 989-993
10.1126/science.aac4263
