Molecular mechanism of the development of thymic epithelial cells
| Project/Area Number |
15K19130
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OHIGASHI Izumi 徳島大学, 先端酵素学研究所(プロテオ), 准教授 (00596588)
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| Research Collaborator |
TAKAHAMA Yousuke
SAKATA Mie
UDDIN Myn
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胸腺 / 獲得免疫 / 胸腺上皮細胞 |
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| Outline of Final Research Achievements |
The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in β5t expression and CD8+ T cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T cell production in the thymus
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.2017
Author(s)
Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.
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Journal Title
Nat Commun
Volume: 8
Issue: 1
Pages: 14419-14419
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Dynamic spatio-temporal contribution of single b5t+ cortical epithelial precursors to the thymus medulla2016
Author(s)
Mayer CE, Zuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Hollander GA.
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Journal Title
European Journal of Immunology
Volume: 46
Issue: 4
Pages: 846-856
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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