Investigation of the role of Menin in immunosenescense and cellular energy metabolism
Project/Area Number |
15K19133
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Immunology
|
Research Institution | Ehime University |
Principal Investigator |
Suzuki Junpei 愛媛大学, 医学系研究科, 助教(特定教員) (20734239)
|
Research Collaborator |
Yasukawa Masaki
Yamashita Masakatsu
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | T細胞老化 / 細胞内エネルギー代謝 / mTORC1 / Menin / 老化 / 代謝 |
Outline of Final Research Achievements |
The deficiency in Menin, a tumor suppressor protein, induces CD8 T-cell senescence. We found that Akt/mTORC1 signaling pathway was enhanced in Menin-deficient activated CD8 T cells. We performed a metabolic profiling of 116 metabolites and found that Menin-deficient activated CD8 T cells had higher rate of glutaminolysis and anaerobic glycolysis than that in the WT activated CD8 T cells. Furthermore, premature CD8 T cell senescence in Menin-deficient CD8 T cells was partially inhibited by the treatment with rapamycin or inhibitors for glutamine metabolism. Theses results suggest that Menin controls CD8 T-cell senescence in part by regulating the energy metabolism.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells2016
Author(s)
Junpei Suzuki, Saho Maruyama, Hidekazu Tamauchi, Makoto Kuwahara, Mika Horiuchi, Masumi Mizuki, Mizuki Ochi, Tatsuya Sawasaki, Jinfang Zhu, Masaki Yasukawa, Masakatsu Yamashita
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Journal Title
Immunology
Volume: 147
Issue: 4
Pages: 476-487
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.2016
Author(s)
Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M.
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Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 12596-12596
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection2016
Author(s)
Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M, and Yamashita M.
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Journal Title
Journal of Immunology
Volume: 197
Issue: 10
Pages: 4079-4089
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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