| Project/Area Number |
15K19133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Ehime University |
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Principal Investigator |
Suzuki Junpei 愛媛大学, 医学系研究科, 助教(特定教員) (20734239)
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| Research Collaborator |
Yasukawa Masaki
Yamashita Masakatsu
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | T細胞老化 / 細胞内エネルギー代謝 / mTORC1 / Menin / 老化 / 代謝 |
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| Outline of Final Research Achievements |
The deficiency in Menin, a tumor suppressor protein, induces CD8 T-cell senescence. We found that Akt/mTORC1 signaling pathway was enhanced in Menin-deficient activated CD8 T cells. We performed a metabolic profiling of 116 metabolites and found that Menin-deficient activated CD8 T cells had higher rate of glutaminolysis and anaerobic glycolysis than that in the WT activated CD8 T cells. Furthermore, premature CD8 T cell senescence in Menin-deficient CD8 T cells was partially inhibited by the treatment with rapamycin or inhibitors for glutamine metabolism. Theses results suggest that Menin controls CD8 T-cell senescence in part by regulating the energy metabolism.
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