| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
Plasmacytoid dendritic cells (pDCs) are important for the innate and adaptive immune responses by producing robust type-I interferon (IFN-I) through the toll-like receptor (TLR)-mediated signaling. However, how pDCs control TLR-mediated immune responses that cause autoimmunity remains unclear. In this study, we demonstrated a critical function of pDCs in the induction of TLR7-mediated innate and adaptive immune responses that cause autoimmunity using gene-modified mice with impaired expression of Siglec-H and selective ablation of pDCs. Our findings reveal that pDCs provide an essential link between TLR7-mediated innate and adaptive immunity for the initiation of IFN-I-associated autoimmune inflammation.
|
