| Project/Area Number |
15K19135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Keio University |
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Principal Investigator |
Nakatsukasa Hiroko 慶應義塾大学, 医学部(信濃町), 特別研究員(PD) (90749334)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 制御性T細胞 / エピジェネティクス / 自己免疫疾患 / TET |
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| Outline of Final Research Achievements |
Regulatory T cells (Tregs) play a pivotal role in regulating immune responses and maintaining immunological tolerance. Although DNA demethylation has been proposed to be essential for the stable expression of Foxp3, a master regulator of Treg, actual contribution of DNA demethylating enzymes (Tet family proteins) in Treg stability and function remain to be elucidated. In this study, we analyzed T cell- or Treg-specific Tet2/3-deficient mice and found that Tet2/3 play important roles in the differentiation, stability and function of T cells and Tregs through regulating DNA demethylation. Furthermore, we have successfully induced region-specific demethylation in Foxp3 gene locus.
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