The role of TET proteins in stability and function of regulatory T cells.
Project/Area Number |
15K19135
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Immunology
|
Research Institution | Keio University |
Principal Investigator |
Nakatsukasa Hiroko 慶應義塾大学, 医学部(信濃町), 特別研究員(PD) (90749334)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 制御性T細胞 / エピジェネティクス / 自己免疫疾患 / TET |
Outline of Final Research Achievements |
Regulatory T cells (Tregs) play a pivotal role in regulating immune responses and maintaining immunological tolerance. Although DNA demethylation has been proposed to be essential for the stable expression of Foxp3, a master regulator of Treg, actual contribution of DNA demethylating enzymes (Tet family proteins) in Treg stability and function remain to be elucidated. In this study, we analyzed T cell- or Treg-specific Tet2/3-deficient mice and found that Tet2/3 play important roles in the differentiation, stability and function of T cells and Tregs through regulating DNA demethylation. Furthermore, we have successfully induced region-specific demethylation in Foxp3 gene locus.
|
Report
(3 results)
Research Products
(15 results)
-
-
[Journal Article] Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy.2017
Author(s)
Kondo T, Morita R, Okuzono Y, Nakatsukasa H, Sekiya T, Chikuma S, Shichita T, Kanamori M, Kubo M, Koga K, Miyazaki T, Kassai Y, and Yoshimura A.
-
Journal Title
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 実験医学増刊2016
Author(s)
吉村昭彦、岡田匡央、金森光広、中司寛子
Total Pages
6
Publisher
羊土社
Related Report
-