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Elucidation of mechanisms for B-cell fate decision by membrane IgE signaling

Research Project

Project/Area Number 15K19138
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionTokyo University of Science

Principal Investigator

Haniuda Kei  東京理科大学, 研究推進機構生命医科学研究所, 助教 (40734918)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords免疫学 / アレルギー / IgE / 胚中心 / メモリーB細胞 / 長期生存プラズマ細胞 / 免疫記憶 / B細胞受容体 / プラズマ細胞
Outline of Final Research Achievements

It is well known that dysregulated production of IgE can be a cause of allergic disorders. Normally, the differentiation of IgE+ B cells into memory-B or long-lived plasma cells is suppressed by unknown mechanisms. However, it has been unclear how the propensity of IgE+ B cells toward short-lived fate is induced. In this study, I revealed molecular mechanisms how the autonomous signaling of membrane IgE (mIgE) suppresses B-cell maintenance. I found that CH1-4 domain of mIgE spontaneously induces cell death through the activation of Syk-BLNK axis and membrane proximal domain of mIgE promotes plasma cell differentiation through CD19-pathway. I also demonstrated that defects of the mIgE-signaling could be a cause of allergy.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Autonomous membrane IgE signaling prevents IgE-memory formation.2016

    • Author(s)
      Haniuda, K., Fukao, S., Kodama, T., Hasegawa, H., Kitamura, D.
    • Journal Title

      Nature Immunology

      Volume: 17 Issue: 9 Pages: 1109-1117

    • DOI

      10.1038/ni.3508

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自発的な膜型免疫グロブリンEのシグナルは免疫グロブリンE型の免疫記憶の形成を抑制する2016

    • Author(s)
      羽生田圭、北村大介
    • Journal Title

      First Author's

      Volume: - Pages: 082

    • DOI

      10.7875/first.author.2016.082

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] 膜型IgEの自発的シグナル伝達によるB細胞記憶形成の制御2016

    • Author(s)
      羽生田圭、深尾紗央里、北村大介
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 65 Pages: 329-333

    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular mechanisms for prevention of IgE-memory formation by membrane IgE2016

    • Author(s)
      Kei Haniuda, Saori Fukao, Tadahiro Kodama, Hitoshi Hasegawa, Daisuke Kitamura
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] The quantity of CD40 signaling in pre-GC phase determine the differentiation into functionally distinct memory B cell subsets via Mef2b expression2016

    • Author(s)
      Takuya Koike, Shu Horiuchi, Kei Haniuda, Daisuke Kitamura
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] A role of membrane-bound IgG1 ubiquitination in B cell activation2016

    • Author(s)
      Tadahiro Kodama, Kei Haniuda, Daisuke Kitamura
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] B細胞補助受容体CD19による胚中心形成メカニズムの解析2016

    • Author(s)
      長谷川仁士、羽生田圭、北村大介
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] CD40-regulated differentiation of memory B cell subsets is independent of isotype and affinity of B-cell antigen receptors.2015

    • Author(s)
      Takuya Koike, Shu Horiuchi, Kei Haniuda, Daisuke Kitamura
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Regulatory mechanisms for memory B cell generation and function.2015

    • Author(s)
      Daisuke Kitamura, Shogo Takatsuka, Hiroshi Saruwatari, Hiroyuki Yamada, Saori Fukao, Kei Haniuda
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] A new primary B cell culture system that can induce somatic hypermutation of immunoglobulin genes.2015

    • Author(s)
      Saori Fukao, Kei Haniuda, Daisuke Kitamura.
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Autonomous signaling from IgE B cell receptor suppresses B cell memory formation.2015

    • Author(s)
      Kei Haniuda, Saori Fukao, Tadahiro Kodama, Hitoshi Hasegawa, Daisuke Kitamura.
    • Organizer
      The 3rd Symposium of International Immunological Memory and Vaccine Forum.
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel regulatory role of gp49B in TD immune response.2015

    • Author(s)
      Saori Fukao, Kei Haniuda, Daisuke Kitamura.
    • Organizer
      The 3rd Symposium of International Immunological Memory and Vaccine Forum.
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 東京理科大学・生命医科学研究所・分子生物学研究部門 北村研究室

    • URL

      http://www.rs.noda.tus.ac.jp/~ribsjm/kitamuralab/indexj.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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