| Project/Area Number |
15K19139
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
Fukuoka Ayumi 兵庫医科大学, 医学部, 助教 (30709754)
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| Research Collaborator |
YOSHIMOTO TOMOHIRO 兵庫医科大学, 医学部, 教授 (60241171)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アレルギー性鼻炎 / 微小粒子状物質 / 鼻粘膜上皮細胞 / タイトジャンクション / PM2.5 |
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| Outline of Final Research Achievements |
It has been considered that PM2.5 is associated with the exacerbation of allergic diseases.The effect of PM2.5 on asthma has been revealed by experimental analysis using mouse models. However, whether PM2.5 exacerbate allergic rhinitis and the mechanism of the exacerbation of allergic rhinitis by PM2.5 is poorly understood. In this study, we revealed that PM2.5 disrupts tight junction between epithelial cells and increases paracellular permeability, resulting in exacerbation of allergic rhinitis.
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