Epidemiological study for the comorbidities in patients with rheumatoid arthritis
Project/Area Number |
15K19162
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
Sakai Ryoko 東京女子医科大学, 医学部, 特任助教 (30631981)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 薬剤疫学 / 関節リウマチ / 分子標的薬 / 合併症 / 安全性 / 生物学的製剤 / 保険データベース / レジストリ |
Outline of Final Research Achievements |
We compared the risk of hospitalized infection, herpes zoster (HZ), cardiovascular disease, stroke, and fracture between patients with and those without rheumatoid arthritis (RA) using the Japanese health insurance database. This study revealed for the first time in Japan that the RA group had significantly higher risks of these complications than the non-RA group did. We investigated the incidence rate (IR) of HZ and associations between medications and HZ in patients with RA using the REAL database. The crude IR (95% confidence intervals) of HZ was 6.7 [4.9-8.8]/1,000 person-years. The adjusted odds ratios (ORs) of tumor necrosis factor inhibitor (TNFI) and oral corticosteroids dosage (per 1 mg prednisolone increment) were significantly elevated. The ORs of non-TNFI and methotrexate usage were not elevated.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] No increased risk of herpes zoster in TNF inhibitor and non-TNF inhibitor users with rheumatoid arthritis: epidemiological study using the Japanese health insurance database2018
Author(s)
Ryoko Sakai, Shoko Kasai, Fumio Hirano, Sayoko Harada, Mari Kihara, Waka Yokoyama, Michi Tsutsumino, Kenji Nagasaka, Ryuji Koike, Hisashi Yamanaka, Nobuyuki Miyasaka, Masayoshi Harigai
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Journal Title
International Journal of Rheumatic Diseases
Volume: 不明
Related Report
Peer Reviewed
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[Presentation] Incidence rate and the risk of herpes zoster in patients with rheumatoid arthritis using Japanese health insurance database2016
Author(s)
Ryoko Sakai, Shoko Kasai, Fumio Hirano, Mari Kihara , Waka Yokoyama, Michi Tsutsumino, Kenji Nagasaka, Ryuji Koike , Hisashi Yamanaka, Nobuyuki Miyasaka, Masayoshi Harigai
Organizer
Annual European Congress of Rheumatology
Place of Presentation
London, England
Year and Date
2016-06-08
Related Report
Int'l Joint Research
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