| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
5‐Fluorouracil (5‐FU) and Irinotecan, an anticancer drug, causes severe gastrointestinal damage, which may affect the absorption of orally administered drugs including the ubstrates of intestinal uptake and efflux transporters. This study aimed to investigate quantitatively the effect of 5‐FU or Irinotecan‐induced intestinal damage on the PK/PD of Dabigatran using rat model. The 5‐FU and Irinotecan‐induced intestinal damage may affect transporter‐mediated drug absorption of orally administered drugs in the clinical setting.
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