| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To elucidate the interaction between the diurnal rhythm of mTOR signal and the circadian clock system, and to find a new therapeutic strategy for cancer and other mTOR related diseases by manipulating mTOR diurnal rhythm, this research was carried out. Two reports on cancer proliferation and biological clock mechanism were published. I also clarified a part of the interaction of the effect of the diurnal rhythm of the mTOR signal and its inhibition on the internal clock mechanism. These findings will find the possibility of application as a new target on the influence of mTOR signal in elucidation and treatment of various diseases such as cancer.
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