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Construction of cancer chronotherapy by manipulation of biological clock via mTOR signal pathway.

Research Project

Project/Area Number 15K19167
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionDaiichi University, College of Pharmaceutical Sciences

Principal Investigator

Okazaki Hiroyuki  第一薬科大学, 薬学部, 助教 (50734125)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsmTOR / がん / 時計遺伝子 / 体内時計 / 薬物療法
Outline of Final Research Achievements

To elucidate the interaction between the diurnal rhythm of mTOR signal and the circadian clock system, and to find a new therapeutic strategy for cancer and other mTOR related diseases by manipulating mTOR diurnal rhythm, this research was carried out. Two reports on cancer proliferation and biological clock mechanism were published. I also clarified a part of the interaction of the effect of the diurnal rhythm of the mTOR signal and its inhibition on the internal clock mechanism. These findings will find the possibility of application as a new target on the influence of mTOR signal in elucidation and treatment of various diseases such as cancer.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness.2016

    • Author(s)
      Takeda S, Himeno T, Kakizoe K, Okazaki H, Okada T, Watanabe K, Aramaki H
    • Journal Title

      Journal of natural medicines

      Volume: 71 Issue: 1 Pages: 286-291

    • DOI

      10.1007/s11418-016-1030-0

    • NAID

      40021062820

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.2016

    • Author(s)
      Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S
    • Journal Title

      The Journal of biological chemistry

      Volume: 291 Issue: 13 Pages: 7017-7028

    • DOI

      10.1074/jbc.m115.713412

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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