Study for mechanisms of drug-induced severe cutaneous reactions
| Project/Area Number |
15K19168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
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| Research Collaborator |
Kanoh Naoki 東北大学, 東北大学大学院薬学研究科, 准教授
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| Project Period (FY) |
2015-03-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | スティーブンス・ジョンソン症候群 / 中毒性表皮壊死症 / HLA / 医薬品 / 分子間相互作用 / 副作用 / ヒト白血球抗原 |
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| Outline of Final Research Achievements |
Recent studies have revealed that the prevalence of Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis (SJS/TEN) is associated with genetic backgrounds, such as polymorphisms in human leukocyte antigens (HLAs). However, molecular mechanism involved in the SJS/TEN onset has been largely unknown. In this project, we developed a system for determination of affinity between drug and HLA protein. This system would be useful for estimation of drug adverse reactions.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] The mevalonate pathway regulates primitive streak formation via protein farnesylation2016
Author(s)
Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Alois RW, Elling U, Penninger JM, Nishina S, Azuma N, Nishina H
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 37697-37697
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Drugs causing severe ocular surface involvements in Japanese patients with StevenseJohnson syndrome/toxic epidermal necrolysis2015
Author(s)
Kaniwa N, Ueta M, Nakamura R, Okamoto-Uchida Y, Sugiyama E, Maekawa K, Takahashi Y, Furuya H, Yagami A, Matsukura S, Ikezawa Z, Matsunaga K, Sotozono C, Aihara M, Kinoshita S, Saito Y.
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Journal Title
Allergology International
Volume: 64
Issue: 4
Pages: 379-381
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Japan Pharmacogenomics Data Science Consortium. Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese.2015
Author(s)
Maekawa K, Nakamura R, Kaniwa N, Mizusawa S, Kitamoto A, Kitamoto T, Ukaji M, Matsuzawa Y, Sugiyama E, Uchida Y, Kurose K, Ueta M, Sotozono C, Ikeda H, Yagami A, Matsukura S, Kinoshita S, Muramatsu M, Ikezawa Z, Sekine A, Furuya H, Takahashi Y, Matsunaga K, Aihara M, Saito Y
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Journal Title
Pharmacogenomics.
Volume: 16
Issue: 15
Pages: 1689-1699
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Drugs and HLA types associated with Stevens–Johnson syndrome/toxic epidermal necrolysis with severe ocular surface involvements in Japanese patients2016
Author(s)
Nakamura R, Kaniwa N, Ueta M, Okamoto-Uchida Y, Sugiyama E, Maekawa K, Takahashi Y, Furuya H, Yagami A, Matsukura S, Ikezawa Z, Matsunaga K, Tokunaga K, Sotozono C, Aihara M, Kinoshita S, Saito Y.
Organizer
1st Internati- onal Stevens- Johnson Syndrome Symposium
Place of Presentation
京都
Year and Date
2016-01-23
Related Report
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[Presentation] 重症眼粘膜障害を伴うSJS/TENの発症と関連する被疑薬およびHLA型について2015
Author(s)
中村亮介, 鹿庭なほ子,上田真由美, 岡本(内田)好海, 杉山永見子, 高橋幸利, 古谷博和, 矢上晶子, 松倉節子, 池澤善郎, 松永佳世子, 徳永勝士, 外園千恵, 相原道子, 木下茂, 斎藤嘉朗
Organizer
第64回日本アレルギー学会学術大会
Place of Presentation
東京
Year and Date
2015-05-26
Related Report
