| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Recently, Chronic Obstructive disease(COPD) is recognized as a systemic inflammatory disease. A variety of mechanisms of the inflammation in COPD are reported; however, the therapeutic approach for the inflammation is not sufficient. The purpose of this project is to investigate the roles of Tumor necrosis factor superfamily member 14 (LIGHT) and Lymphotoxin beta receptor (LTβR) signaling in COPD through both basic cell researches and development of a COPD animal model. We developed the COPD mice model, and LTβR was induced in the lung of COPD model mice. Our findings suggested that LTβR might be a disease marker and therapeutic target of COPD.
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