Contribution of LTBR signaling for development of COPD

• Project/Area Number: 15K19172
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Mikami Yu 東京大学, 医学部附属病院, 特任臨床医 (50732806)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: COPD / 肺気腫 / マウスモデル / LTBR / マイクロアレイ / LIGHT / LTβR / 喫煙 / 肺機能

Outline of Final Research Achievements

Recently, Chronic Obstructive disease(COPD) is recognized as a systemic inflammatory disease. A variety of mechanisms of the inflammation in COPD are reported; however, the therapeutic approach for the inflammation is not sufficient. The purpose of this project is to investigate the roles of Tumor necrosis factor superfamily member 14 (LIGHT) and Lymphotoxin beta receptor (LTβR) signaling in COPD through both basic cell researches and development of a COPD animal model. We developed the COPD mice model, and LTβR was induced in the lung of COPD model mice. Our findings suggested that LTβR might be a disease marker and therapeutic target of COPD.

Research Products

• [Journal Article] TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts. (2017)
  • Author(s): Noguchi S, Saito A, Mikami Y, Urushiyama H, Horie M, Matsuzaki H, Takeshima H, Makita K, Miyashita N, Mitani A, Jo T, Yamauchi Y, Terasaki Y, Nagase T.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 42595-42595
  • DOI: 10.1038/srep42595
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition. (2016)
  • Author(s): Mikami Y, Matsuzaki H, Takeshima H, Makita K, Yamauchi Y, Nagase T.
  • Journal Title: J Vis Exp Volume: 112 Issue: 112
  • DOI: 10.3791/53974
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum Reactive Oxygen Metabolite Levels Predict Severe Exacerbations of Asthma. (2016)
  • Author(s): Nakamoto K, Watanabe M, Sada M, Inui T, Nakamura M, Honda K, Wada H, Mikami Y, Matsuzaki H, Horie M, Noguchi S, Yamauchi Y, Koyama H, Kogane T, Kohyama T, Takizawa H.
  • Journal Title: PLoS One Volume: - Issue: 10 Pages: e0164948-e0164948
  • DOI: 10.1371/journal.pone.0164948
  • Peer Reviewed / Open Access
• [Journal Article] Development of an in vitro assay to evaluate contractile function of mesenchymal cells that underwent epithelial-mesenchymal transition (2016)
  • Author(s): Yu Mikami
  • Journal Title: Journal of Visualized Experiments Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Evaluation of incidental lung cancer in hospitalized patients with nonrespiratory disease (2016)
  • Author(s): Naoya Miyashita, Yu Mikami, Hidenori Kage, Kosuke Makita, Hideyuki Takeshima, Hirotaka Matsuzaki, Yasuhiro Yamauchi, Goh Tanaka, Daiya Takai, Yutaka Yatomi, Takahide Nagase
  • Organizer: European Respiratory Society 2016 International Congress
  • Place of Presentation: London
  • Year and Date: 2016-09-06
  • Int'l Joint Research
• [Presentation] Respiratory manifestations in hospitalized patients with hematological malignancies (2015)
  • Author(s): Yu Mikami
  • Organizer: European Respiratory Society
  • Place of Presentation: Amsterdam
  • Year and Date: 2015-09-28
  • Int'l Joint Research
• [Presentation] Montelukast Inhibits Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Differentiation (2015)
  • Author(s): Yu Mikami
  • Organizer: American Thoracic Society
  • Place of Presentation: Denver
  • Year and Date: 2015-05-19
  • Int'l Joint Research