Whole genome analysis of ESBL-producing E. coli ST131 clone and definition of its responsible subclone
Project/Area Number |
15K19179
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Laboratory medicine
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 全ゲノム解析 / 薬剤耐性菌 / クローン / クローン同定 / 世界流行型クローン / パンデミッククローン |
Outline of Final Research Achievements |
Escherichia coli is one of the most common pathogen in humans. Recent increase in drug-resistant E. coli is an emerging public health threat and is driven by clonal spread of a specific bacterial lineage with drug resistant mechanisms, called ST131. We performed whole genome sequencing analysis of ESBL-producing E. coli collected from multiple Japanese acute care hospitals. CTX-M-27-producing ST131, the most common type in Japan belonged to a novel subclone and was also present outside Japan. The discovery of this novel subclone, named C1-M27, will contribute control of drug resistant E. coli.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Global Escherichia coli Sequence Type 131 Clade with blaCTX-M-27 Gene2016
Author(s)
Yasufumi Matsumura, Johann D.D. Pitout, Ryota Gomi, Tomonari Matsuda, Taro Noguchi, Masaki Yamamoto, Gisele Peirano, Rebekah DeVinney, Patricia A. Bradford, Mary R. Motyl, Michio Tanaka, Miki Nagao, Shunji Takakura, and Satoshi Ichiyama
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Journal Title
Emerging Infectious Diseases
Volume: 22
Issue: 11
Pages: 1900-1907
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] The emergence of Escherichia coli ST131 H30 that produce CTX-M-27 in Japan.2016
Author(s)
Y. Matsumura, R. Gomi, T. Matsuda, J. Pitout, R. DeVinney, M. Yamamoto, T. Noguchi, M. Nagao, M. Tanaka, S. Ichiyama
Organizer
The 26th European Congress of Clinical Microbiology and Infectious Diseases
Place of Presentation
Amsterdam, Netherlands
Related Report
Int'l Joint Research