| Project/Area Number |
15K19179
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 全ゲノム解析 / 薬剤耐性菌 / クローン / クローン同定 / 世界流行型クローン / パンデミッククローン |
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| Outline of Final Research Achievements |
Escherichia coli is one of the most common pathogen in humans. Recent increase in drug-resistant E. coli is an emerging public health threat and is driven by clonal spread of a specific bacterial lineage with drug resistant mechanisms, called ST131. We performed whole genome sequencing analysis of ESBL-producing E. coli collected from multiple Japanese acute care hospitals. CTX-M-27-producing ST131, the most common type in Japan belonged to a novel subclone and was also present outside Japan. The discovery of this novel subclone, named C1-M27, will contribute control of drug resistant E. coli.
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