| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We previously reported that Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells. In order to determine the role for MED1 in the property of breast carcinomas, prognosis, and response to therapy, we have prepared, or are in the process of preparing, mice carrying various mutations in MED1 and MED1-associated factor. We have analysed these mutant mice that have been ready so far if these mice possess the ability of inhibiting breast cancer.
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