| Project/Area Number |
15K19185
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Koyama Teruhime 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40711362)
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| Research Collaborator |
WATANABE Yoshiyuki 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00191809)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Adrenomedullin / MR-proADM / 生活習慣病 / 慢性炎症 / 疫学 / 高血圧症 / 脂質異常症 / 糖尿病 / adrenomedullin / 臓器障害 |
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| Outline of Final Research Achievements |
Adrenomedullin (ADM) is now known to be secreted from various organs and serves numerous physiological functions. These cover the use of ADM in diagnosis and as a biomarker for prognosis. However, reliable measurement of ADM is challenging due to its short half-life. The increased stability of its precursor molecule, midregional proADM (MR-proADM), allows it to be reliably measured as a surrogate biomarker for the ADM. We established two methods of measurement MR-proADM; time-resolved amplified cryptate emission and an enzyme immunoassay.
This study was designed to explore the predictive value of the MR-proADM in assessing the lifestyle-related disease. Among these 1298 participants, the mean MR-proADM of the included 431 men was 0.469 nmol/l, compared to 0.414 nmol/l for the 867 women. Men and women showed hypertension, dyslipidemia, obesity and diabetes were higher MR-proADM than control. These results suggest that MR-proADM could a novel biomarker for the lifestyle-related disease.
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