| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The peritoneal deterioration is associated with encapsulating peritoneal sclerosis which is the most serious complication of peritoneal dialysis. We identified novel biomarkers in peritoneal effluent to predict peritoneal deterioration in peritoneal dialysis. ERC/mesothelin is expressed in normal mesothelial cells, and is cleaved by a furin-like protease into two fragments: secreted N-ERC/mesothelin and membrane-bound C-ERC/mesothelin. We examined whether ERC/mesothelin predicts peritoneal deterioration. There were significant correlation between peritoneal function (D/P Cr) and N-ERC/mesothelin in peritoneal effluent. In multivariate analysis, N-ERC/mesothelin in peritoneal effluent was identified as an independent predictor of peritoneal deterioration even after adjusting for age, duration of peritoneal dialysis, and glomerular filtration rate. We concluded that N-ERC/mesothelin in peritoneal effluent predicts peritoneal deterioration.
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