Development of immunoserological diagnostic methods for fungal-allergic patients inflood-damaged areas
| Project/Area Number |
15K19188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
MAIKO WATANABE 国立医薬品食品衛生研究所, 衛生微生物部, 室長 (00432013)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBOSAKI Atsutaka 国立医薬品食品衛生研究所, 衛生微生物部, 主任研究官 (30425673)
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| Research Collaborator |
KAMATA Yoichi
TSURIKISAWA Naomi
OSHIKATA Chiyako
KIMURA Noritaka
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 水害被災住宅 / 室内真菌叢 / 抗原特異的IgE / 化学発光酵素免疫測定法 / Aspergillus restrictus / Eurotium amstelodami / 浸水一戸建 / 応急仮設住宅 / アレルギー・免疫関連疾患 / 抗体 / 真菌 / ダニ / 喘息 |
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| Outline of Final Research Achievements |
We developed the Chemiluminescent Enzyme Immunoassay (CLEIA) method for the detection of anti-fungal allergen antibody(IgE) for fungal-allergic patients in flood-damaged areas, with Aspergillus species and their related species which are the most allergic fungi. Our results indicated that positive rates for several allergic fungi among the dwellers in flood-damaged areas were in the range of 7.0-15.1% by the CLEIA method.
Because the growth of mites in the housedust is well correlated with the growth of fungi, we acquired the anti-Der_f_1 and Der_1 monoclonal antibody to construct the detection method for allergen of the genus Dermatophagoides in the future study.
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Report
(3 results)
Research Products
(5 results)
