Study on standardization of HDR image guided brachytherapy

• Project/Area Number: 15K19207
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Saitama Medical University
• Principal Investigator: Kumazaki Yu 埼玉医科大学, 医学部, 講師 (10535488)
• Research Collaborator: Hirai Ryuta ; Igari Mitsunobu
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ３次元画像誘導小線源治療 / 3D-IGBT / QA/QC / 画像誘導小線源治療 / 線源停留位置精度 / 品質管理システム / QAファントム

Outline of Final Research Achievements

We established quality assurance methods of source positions, source strength, and dose distribution to standardize safe, and high-precision three-dimensional image-guided brachytherapy (3D IGBT) in terms of medical physics. We had a patent application on the tools developed in this study, and commercialized these (Japanese Patent Application No.2015-079169). These tools can be contributory to quality assurance performed by brachytherapy user in Japan. Also, these are available as postal audit system for credentialing of 3D-IGBT in the designated regional cancer centers and hospitals in Japan.

Research Products

• [Journal Article] A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using interstitial brachytherapy: treatment planning and quality assurance. Radiation Oncology (2015)
  • Author(s): 17.Otani Y, Nose T, Dokiya T, Saeki T, Kumazaki Y, Asahi S, Tsukiyama I, Fukuda I, Sekine H, Shikama N, Takahashi T, Yoshida K, Kotsuma T, Masuda N, Yoden E, Nakashima K, Matsumura T, Nakagawa S, Tachiiri S, Moriguchi Y, Itami J and Oguchi M
  • Journal Title: Radiation Oncology Volume: 10 Issue: 1 Pages: 126-133
  • DOI: 10.1186/s13014-015-0430-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] IGBTが及ぼす利益と課題 (2016)
  • Author(s): 熊崎 祐
  • Organizer: 日本放射線技術学会
  • Place of Presentation: 大宮ソニックシティ（埼玉県さいたま市）
  • Invited
• [Presentation] 小線源治療物理と品質管理 (2016)
  • Author(s): 熊崎 祐
  • Organizer: 日本放射線腫瘍学会小線源部会
  • Place of Presentation: ホテルエルセラーン大阪（大阪府大阪市）
  • Invited
• [Presentation] 画像誘導放射線治療の省力化 (2016)
  • Author(s): 熊崎 祐
  • Organizer: 日本放射線腫瘍学会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Invited
• [Presentation] Development of a high-dose rate brachytherapy quality assurance tool for verification of source positionwith Oncentra applicator modeling (2015)
  • Author(s): Kumazaki Y, Miyaura K, Hirai R, Miyazawa K, Makino S, Tamaki T, Shikama N, Kato S
  • Organizer: Japanese Society for Therapeutic Radiology and Oncology
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-20
• [Presentation] 画像誘導放射線治療 (2015)
  • Author(s): 熊崎祐
  • Organizer: 日本放射線腫瘍学会
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-20
  • Invited
• [Presentation] Development of a HDR-BT QA Tool for Verification of Source Position with Oncentra Applicator (2015)
  • Author(s): Kumazaki Y, Miyaura K, Ryuta H, Miyazawa K, Makino S, Tamaki T, Shikama N, Kato S
  • Organizer: American Association of Physicists in Medicine (AAPM) annual meeting 2016
  • Place of Presentation: Anaheim Convention Center(Anaheim CA.)
  • Year and Date: 2015-07-11
• [Book] がん・放射線療法2017 (2017)
  • Author(s): 熊崎 祐
  • Total Pages: 8
  • Publisher: 学研メディカル秀潤社
• [Book] 放射線医科学-生体と放射線・電磁波・超音波- (2016)
  • Author(s): 熊崎 祐、加藤 眞吾
  • Total Pages: 4
  • Publisher: 医療科学社
• [Book] 放射線治療物理学 (2016)
  • Author(s): 熊崎祐（編者：荒木不次男）
  • Total Pages: 319
  • Publisher: 国際文献社
• [Book] 外部放射線治療におけるQuality Assurance(QA)システムガイドライン 2016年版 (2016)
  • Author(s): 熊崎祐（編集：公益社団法人 日本放射線腫瘍学会）
  • Total Pages: 160
  • Publisher: 金原出版株式会社
• [Patent(Industrial Property Rights)] ガイドワイヤー先端小線源のアプリケーター内停止位置の検査方法および検査具 (2016)
  • Inventor(s): 熊崎 祐
  • Industrial Property Rights Holder: 熊崎 祐
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-079160
  • Filing Date: 2016-04-08
• [Patent(Industrial Property Rights)] 2.ガイドワイヤー先端小線源のアプリケーター内停止位置の検査方法および検査具 (2015)
  • Inventor(s): 熊崎祐
  • Industrial Property Rights Holder: 埼玉医科大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-04-08