Development of risk adjustment method for longitudinal epidemiological research using the Japanese National Insurance Claims Database

• Project/Area Number: 15K19220
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Institute of Public Health (2016-2017); The University of Tokyo (2015)
• Principal Investigator: SATO DAISUKE 国立保健医療科学院, その他部局等, 主任研究官 (10646996)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: レセプト情報等データベース / 脳血管疾患 / レセプト情報 / 臨床疫学 / データベース / 社会医学 / 統計解析 / 医療保険 / 医療経済学

Outline of Final Research Achievements

Non-vitamin K antagonist oral anticoagulant (NOAC) is approved to anticoagulant for minimizing the risk of recurrence like stroke or transient ischemic attack (TIA) in patients with non-valvular atrial fibrillation (NVAF).
Our study evaluated the long-term effectiveness of NOAC and VKA in patients with NVAF using the Japanese National Insurance Claims Database (NDB). A major strength of the NDB is its exhaustiveness or completeness of insurance claims.
Endpoint of (ischemic) stroke and TIA presented no significant difference between NOACs and VKAs. Treatment days from of NOACs is shorter than VKAs, but the reimbursement payment of NOACs is more 1.6 higher than VKAs.

Research Products

• [Presentation] The Construction Of Database Using Japanese National Claims Database (2017)
  • Author(s): Daisuke SATO
  • Organizer: Health にTechnology Assessment international
  • Place of Presentation: Itaky ROME
  • Year and Date: 2017-06-16
  • Int'l Joint Research
• [Presentation] 非弁膜症性心房細動を有する脳梗塞または一過性脳虚血発作(TIA)予防のための 抗凝固療法に用いるVKAとNOACの経済評価 (2017)
  • Author(s): 佐藤 大介
  • Organizer: 第12回 医療経済学会
• [Presentation] The Construction Of Database Using Japanese National Claims Database (2017)
  • Author(s): Daisuke Sato, Takeru Shiroiwa, Takashi Fukuda
  • Organizer: HTAi 2017 Annual Meeting
• [Presentation] レセプト情報等オンサイトリサーチセンターの試行的利用について (2016)
  • Author(s): 佐藤 大介,大江 和彦
  • Organizer: 第22回日本薬剤疫学会学術総会
  • Place of Presentation: 京都 みやこめっせ
  • Year and Date: 2016-11-18
• [Book] Databases for Pharmacoepidemiological Research Japan - National Insurance Claims Database(NDB) (2017)
  • Author(s): Daisuke SATO, Kazuhiko Ohe
  • Publisher: Springer Series
• [Book] Databases for Pharmacoepidemiological Research Japan - National Insurance Claims Database (NDB) (2016)
  • Author(s): Daisuke Sato and Kazuhiko Ohe
  • Publisher: Springer Series