Serum irisin and obesity, diabetes mellitus, and atherosclerosis

• Project/Area Number: 15K19224
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Shimane University (2016); Shiga University of Medical Science (2015)
• Principal Investigator: Hisamatsu Takashi 島根大学, 医学部, 准教授 (60710449)
• Research Collaborator: MIURA Katsuyuki 滋賀医科大学, 社会医学講座公衆衛生学部門, 教授 (90257452) ; UESHIMA Hirotsugu 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483) ; FUJIYOSHI Akira 滋賀医科大学, 社会医学講座公衆衛生学部門, 准教授 (10567077)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: イリシン / 疫学 / 肥満 / 糖尿病 / 動脈硬化

Outline of Final Research Achievements

Irisin is a newly discovered myokine. We aimed to examine to the association of serum irisin and obesity, diabetes mellitus, and atherosclerosis. In a community-based apparently healthy adults aged 40-79 years, serum irisin was inversely associated with obesity and lipid indices. In addition, serum irisin was inversely associated with progression of coronary artery calcification independent of confounders including obesity, lipid, and diabetes parameters. Future studies are needed to assess whether irisin is protectively associated with cardiometabolic disease.

Research Products

• [Journal Article] Step counts measured with a pedometer and risk of incident metabolic syndrome: a 5-year follow-up of population-based cohort (Shiga Epidemiological Study of Subclinical Atherosclerosis, SESSA) (2017)
  • Author(s): Hisamatsu T, Miura K, Shibukawa T, Fujiyoshi A, Miyagawa N, Sayuki T, Kondo K, Miyazawa I, Suzuki S, Satoh A, Yamazoe M, Yanagita M, Maegawa H, Ueshima H
  • Journal Title: Japanese Journal of Cardiovascular Disease Prevention Volume: 52 Pages: 20-28
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Increased aortic calcification is associated with arterial stiffness progression in multi ethnic middle-aged men. (2017)
  • Author(s): Guo J, Fujiyoshi A, Willcox B, Choo J, Vishnu A, Hisamatsu T, Ahuja V, Takashima N, Barinas-Mitchell E, Kadota A, Evans RW, Miura K, Edmundowicz D, Masaki K, Shin C, Kuller LH, Ueshima H, Sekikawa A; ERA JUMP Study Group.
  • Journal Title: Hypertension Volume: 69 Pages: 102-108
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men. (2016)
  • Author(s): Hisamatsu T, Miura K, Arima H, Kadota A, Kadowaki S, Torii S, Suzuki S, Miyagawa N, Sato A, Yamazoe M, Fujiyoshi A, Ohkubo T, Yamamoto T, Murata K, Abbott RD, Sekikawa A, Horie M, Ueshima H; Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group
  • Journal Title: J Am Heart Assoc. Volume: 29 Issue: 9
  • DOI: 10.1161/jaha.116.003738
  • NAID: 120006334825
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components: Shiga Epidemiological Study of Subclinical Atherosclerosis. (2016)
  • Author(s): Yamazoe M, Hisamatsu T, Miura K, Kadowaki S, Zaid M, Kadota A, Torii S, Miyazawa I, Fujiyoshi A, Arima H, Sekikawa A, Maegawa H, Horie M, Ueshima H; SESSA Research Group.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 8 Pages: 1703-1708
  • DOI: 10.1161/atvbaha.116.307612
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lipoprotein-associated phospholipase A2 related to the risk of subclinical atherosclerosis independent of small low density lipoprotein particles in a general Japanese population. (2016)
  • Author(s): Ueshima H, Kadowaki T, Fujiyoshi A, Miura K, Ohkubo T, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, et ai.
  • Journal Title: Athelosclerosis Volume: 246 Pages: 141-147
  • DOI: 10.1016/j.atherosclerosis.2015.12.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese men (2017)
  • Author(s): Hisamatsu T, Miura K, Arima H, Kadota A, Kadowaki S, Torii S, Suzuki S, Miyagawa N, Sato A, Yamazoe M, Fujiyoshi A, Ohkubo T, Yamamoto T, Murata K, Abbott RD, Sekikawa A, Horie M, Ueshima H
  • Organizer: 第49回日本動脈硬化学会学術集会, 若手研究者奨励賞
  • Place of Presentation: グランドプリンスホテル広島, 広島
  • Year and Date: 2017-07-06
• [Presentation] Prevalence of Intracranial Artery Stenosis and the Association with Conventional Risk Factors of Cardiovascular Diseases in a General Population of Japanese: SESSA Study (2017)
  • Author(s): Shitara S, Fujiyoshi A, Hisamatsu T, Torii S, Suzuki S, Ito T, Arima H, Shiino A, Nozaki K, Miura K, Ueshima H; SESSA research group
  • Organizer: American Heart Association's Epidemiology and Prevention/Lifestyle and Cardiometabolic Health 2017
  • Place of Presentation: Hilton Portland and Executive Tower, Portland, OR, USA
  • Year and Date: 2017-03-07
  • Int'l Joint Research
• [Presentation] Risk Factors for the Progression and Incidence of Aortic Calcification in an International Multiethnic Cohort of Men Aged 40-49 Years: ERA JUMP Study (2017)
  • Author(s): Shangguan S, Guo J, Mahajan H, Masaki K, Willcox BJ, Miura K, Ueshima H, Fujiyoshi A, Hisamatsu T, Kuller LH, Barinas-Mitchell EJ, Edmundowicz D, Sekikawa A.
  • Organizer: American Heart Association's Epidemiology and Prevention/Lifestyle and Cardiometabolic Health 2017
  • Place of Presentation: Hilton Portland and Executive Tower, Portland, OR, USA
  • Year and Date: 2017-03-07
  • Int'l Joint Research
• [Presentation] 客観的に評価された歩数値とメタボリック症候群との関連：地域住民5年前向き研究（滋賀動脈硬化疫学研究SESSA） (2016)
  • Author(s): 久松隆史、三浦克之、渋川武志、藤吉朗、有馬久富、門田文、宮川尚子、鳥居さゆ希、近藤慶子、宮澤伊都子、鈴木仙太朗、佐藤敦、山添正博、上島弘嗣
  • Organizer: 第52回日本循環器病予防学会学術集会
  • Place of Presentation: 埼玉県県民健康センター, 埼玉
  • Year and Date: 2016-06-17
• [Presentation] Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification beyond Metabolic Syndrome in a General Population (2016)
  • Author(s): Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Takashi Kadowaki, Akira Fujiyoshi, Robert Abbott, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group
  • Organizer: AHA EPI Lifestyle 2016
  • Place of Presentation: Phoenix
  • Year and Date: 2016-03-01
  • Int'l Joint Research
• [Presentation] 喫煙習慣、喫煙指数、禁煙期間と潜在性動脈硬化との関連：滋賀動脈硬化疫学研究SESSA (2016)
  • Author(s): 久松隆史、三浦克之、有馬久富、門脇紗也佳、鳥居さゆ希、鈴木仙太朗、宮川尚子、門田文、藤吉朗、大久保孝義、上島弘嗣
  • Organizer: 第26回日本疫学会学術総会、米子、2016年1月21-23日
  • Place of Presentation: 米子
  • Year and Date: 2016-01-21
• [Presentation] 潜在性動脈硬化の規定要因：ERA JUMP、SESSAより (2015)
  • Author(s): 久松隆史、三浦克之、関川暁、上島弘嗣
  • Organizer: 第47回日本動脈硬化学会総会・学術集会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2015-07-09
• [Remarks] 滋賀医科大学アジア疫学研究センターウェブサイト
  • URL: https://cera.shiga-med.ac.jp/
• [Remarks] 滋賀医科大学アジア疫学研究センター
  • URL: https://cera.shiga-med.ac.jp/
• [Remarks] 動脈硬化と認知症に関する疫学研究 滋賀動脈硬化疫学研究 SESSA セッサ
  • URL: https://hs-web.shiga-med.ac.jp/sessa/index.html