| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We aimed to investigate the predictive value of baseline interleukin-6 (IL-6), C-reactive protein (CRP) and gene variants [IL-6 receptor (IL-6R), rs2228145; IL-6, rs2097677; CRP, rs3093059] for dementia risk in patients with vascular risk factors who are initially cognitively intact. In multivariable analyses adjusted for covariates and IL-6R variant (rs2228145), IL-6 levels for dementia remained significant. Although subjects with rs2228145 carrier had significantly higher IL-6 levels, a significant association between rs2228145 and dementia was not observed. We also explored the predictive value of baseline homocysteine or circulating levels of eicosapentaenoic acid, docosahexaenoic acid [DHA], dihomo-γ-linolenic acid, and arachidonic acid for dementia risk. The effect of IL-6, homocysteine, or DHA for dementia risk remain consistent irrespective of conventional risk factors including apolipoprotein Eε4, cerebral small-vessel disease and brain atrophy.
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