The association between cerebral microbleeds and cardio-ankle vascular index

• Project/Area Number: 15K19230
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Nagasaki University
• Principal Investigator: YAMANASHI Hirotomo 長崎大学, 医歯薬学総合研究科(医学系), 助教 (60709864)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脳卒中 / 細動脈硬化症 / Cerebral microbleeds / cerebral microbleeds / 頭部MRI / 頭部MR

Outline of Final Research Achievements

Atherosclerosis is classified as the two types; arteriosclerosis which is a thickness of medium or large arteries, and arteriolosclerosis which is hardening of small arteries. In vivo, it is difficult to differentiate these two. The aim of this study is to investigate the association between cerebral microbleeds (CMB) and cardio-ankle vascular index (CAVI). The participants were enrolled from the adult out-patients in the secondary hospital who were undertaken the brain plain MRI without dementia or past history of stroke. We obtained the written informed consent and collected the medical history, and evaluated CAVI value. Out of 97 participants, 19 had any CMB. In the logistic analysis, there was no association between CMB and CAVI after adjustments for classical cardiovascular risk factors. We concluded that not CAVI, but CMB is a beneficial indicator to assess the arteriolosclerosis in the brain.

Research Products

• [Journal Article] Multiple somatic symptoms and frailty: cross-sectional study in Japanese community-dwelling elderly people. (2016)
  • Author(s): Yamanashi H, Shimizu Y, Koyamatsu J, Nobuyoshi M, Nagayoshi M, Kadota K, Tamai M, Maeda T
  • Journal Title: Fam Pract Volume: 33 Issue: 5 Pages: 453-460
  • DOI: 10.1093/fampra/cmw028
  • NAID: 120006987218
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Population-Based Incidence Rates of First-Ever Stroke in Central Vietnam (2016)
  • Author(s): Yamanashi H, Ngoc MQ, Huy TV, Suzuki M, Tsujino A, Toizumi M, Takahashi K, Thiem VD, Anh DD, Anh NT, Tho le H, Maeda T, Cox SE, Yoshida LM, Ariyoshi K
  • Journal Title: Plos One Volume: 11 Issue: 8 Pages: e0160665-e0160665
  • DOI: 10.1371/journal.pone.0160665
  • NAID: 120006987217
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circulating CD34-positive cells are associated with handgrip strength in Japanese older men. (2016)
  • Author(s): Yamanashi H, Shimizu Y, Koyamatsu J, Nagayoshi M, Kadota K, Tamai M, Maeda T
  • Journal Title: Journal of Frailty and Aging Volume: 6 Pages: 6-11
  • DOI: 10.14283/jfa.2016.107
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between adult short stature and cerebral microbleeds (2016)
  • Author(s): Yamanashi H, Shimizu Y, Nagaoki K, Murase K, Koyamatsu J, Nobuyoshi M, Nagayoshi M, Kadota K, Tamai M, Tateishi Y, Tsujino A, Maeda T
  • Journal Title: International Journal of Stroke Volume: 11 Issue: 2 Pages: NP27-NP29
  • DOI: 10.1177/1747493015620810
  • NAID: 120006987283
  • Peer Reviewed
• [Journal Article] The association between living alone and frailty in a rural Japanese population: the Nagasaki Islands study (2015)
  • Author(s): Yamanashi H, Shimizu Y, Nelson M, Koyamatsu J, Nagayoshi M, Kadota K, Tamai M, Ariyoshi K, Maeda T
  • Journal Title: Journal of Primary Health Care Volume: 7 Pages: 269-273
  • NAID: 120006987284
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exercise-Induced Pulmonary Edema in a Triathlon (2015)
  • Author(s): Yamanashi H, Koyamatsu J, Nobuyoshi M, Murase K, Maeda T
  • Journal Title: Case reports in medicine Volume: - Pages: 968152-968152
  • DOI: 10.1155/2015/968152
  • NAID: 120006987285
  • Peer Reviewed
• [Presentation] トライアスロンで発症した運動誘発性肺水腫 (2016)
  • Author(s): 山梨啓友、小屋松淳、前田隆浩
  • Organizer: 日本プライマリ・ケア連合学会長崎支部会
  • Place of Presentation: 長崎大学医学部基礎研究棟（長崎県、長崎市）
  • Year and Date: 2016-01-30
• [Presentation] Circulating CD34 positive cells are associated with handgrip strength in Japanese elderly men. (2016)
  • Author(s): Hirotomo Yamanashi, Yuji Shimizu, Jun Koyamatsu, Masaharu Nobuyoshi, Mako Nagayoshi, Koichiro Kadota, Mami Tamai, and Takahiro Maeda
  • Organizer: 第7回日本プライマリ・ケア連合学会学術大会
  • Place of Presentation: 浅草ビューホテル3階祥雲Ⅰ（東京都台東区）
• [Presentation] 脳MRにおける微小出血(Cerebral Microbleeds)と身長との関連 (2015)
  • Author(s): 山梨啓友、清水悠路、小屋松淳、永吉真子、玉井慎美、前田隆浩
  • Organizer: 第74回日本公衆衛生学会
  • Place of Presentation: 長崎新聞文化ホール（長崎県、長崎市）
  • Year and Date: 2015-11-05
• [Presentation] he association between single household family structures and frailty in a rural Japanese male population (2015)
  • Author(s): Hirotomo Yamanashi, Yuji Shimizu, Mark Nelson, Jun Koyamatsu, Mako Nagayoshi, Koichiro Kadota, Koya Ariyoshi, and Takahiro Maeda
  • Organizer: 第六回日本プライマリ・ケア連合学会学術大会
  • Place of Presentation: つくば国際会議場（茨城県、つくば市）
  • Year and Date: 2015-06-13
• [Presentation] The association between single household family structures and frailty in a rural Japanese population: the Nagasaki Islands study (2015)
  • Author(s): Yamanashi H, Shimizu Y, Nelson M, Koyamatsu J, Nagayoshi M, Kadota K, Tamai M, Ariyoshi K, Maeda T
  • Organizer: International Conference on Frailty and Sarcopenia Research
  • Place of Presentation: ボストン（米国）
  • Year and Date: 2015-04-23
  • Int'l Joint Research
• [Presentation] 中央ベトナムにおいて入院した脳卒中患者の発生率および致命率に関する研究 (2015)
  • Author(s): 山梨啓友、鈴木基、西田レイミント、清水悠路、前田隆浩、有吉紅也
  • Organizer: 第112回日本内科学会
  • Place of Presentation: みやこめっせ（京都府、京都市）
  • Year and Date: 2015-04-11