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Examination the effect of lactation on protection of pancreatic Bcell mass and preventing type 2 diabetes mellitus in women with gestational diabetes mellitus

Research Project

Project/Area Number 15K19234
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionNational Center for Child Health and Development

Principal Investigator

Maki Kawasaki  国立研究開発法人国立成育医療研究センター, 政策科学研究部, 非常勤医師 (00747488)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords妊娠糖尿病 / 授乳 / 2型糖尿病 / 膵臓β細胞保護 / 糖尿病発症予防
Outline of Final Research Achievements

Recently, it has been reported from Western studies that lactation is associated with lower incidences of type 2 diabetes after gestational diabetes mellitus(GDM )pregnancy.In this study, we examined the effect of lactation on protection of pancreatic Bcell mass and preventing type 2 diabetes mellitus in women with GDM. We found no association between lactation intensity or lactation duration and incidences of type 2 diabetes.In exclusive lactation (no formula) group at 1 to 3 months after delivery ,HOMA-R at 3 months after birth and 1 year after birth was significantly lower and Disposition Index(DI) at 3 months after birth was significantly higher than that of incomplete lactation milk(formula,formula+lactation)group.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] Obesity and abnormal glucose tolerance in offspring of diabetic mothers: A systematic review and meta-analysis2018

    • Author(s)
      Kawasaki Maki、Arata Naoko、Miyazaki Celine、Mori Rintaro、Kikuchi Toru、Ogawa Yoshihiro、Ota Erika
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: 1-19

    • DOI

      10.1371/journal.pone.0190676

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonpharmacological interventions to prevent type 2 diabetes in women diagnosed with gestational diabetes mellitus: a systematic overview2017

    • Author(s)
      Miyazaki Celine、Tanase-Nakao Kanako、Arata Naoko、Mori Rintaro、Kawasaki Maki、Ota Erika
    • Journal Title

      Diabetology International

      Volume: 8 Issue: 2 Pages: 160-180

    • DOI

      10.1007/s13340-017-0316-0

    • NAID

      40021217981

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Potential protective effect of lactation against incidence of type 2 diabetes in women with previous gestational diabetes mellitus: A systematic review and meta‐analysis.2016

    • Author(s)
      Tanase‐Nakao K, Arata N, Kawasaki M, Yasuhi I, Sone H, Mori R, Ota E.
    • Journal Title

      Diabetes/Metabolism Research and Reviews.(IF3.064)

      Volume: 33(4) Issue: 4 Pages: 1-9

    • DOI

      10.1002/dmrr.2875

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 既往妊娠糖尿病女性の2型糖尿病発症予防法について ―最新の海外の知見―2016

    • Author(s)
      川﨑麻紀、荒田尚子
    • Journal Title

      Diabetes Frontier

      Volume: Vol27,No5 Pages: 622-627

    • Related Report
      2016 Research-status Report
  • [Presentation] 妊娠糖尿病発症女性の産後3ヵ月以内の糖負荷試験時におけるその後の糖尿病発症 リスク因子の同定2017

    • Author(s)
      川﨑麻紀、荒田尚子、和栗雅子、安日一郎、長村杏奈、佐藤志織、坂本なほ子、小川佳宏
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 妊娠前非肥満の妊娠糖尿病既往女性における妊娠中に分かる産後糖尿病発症リスク因子の同定2017

    • Author(s)
      川﨑麻紀、荒田尚子、和栗雅子、安日一郎、長村杏奈、佐藤志織、坂本なほ子、小川佳宏
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 妊娠糖尿病既往女性の産後2型糖尿病発症について2016

    • Author(s)
      川﨑麻紀、荒田尚子、小川佳宏
    • Organizer
      第26回臨床内分泌Update
    • Place of Presentation
      大宮
    • Year and Date
      2016-11-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 妊娠糖尿病既往・産後境界型糖尿病女性へのメトホルミン投与による糖尿病発症抑制を検証するオープンランダム化比較試験の概要2016

    • Author(s)
      川﨑麻紀,佐藤志織,小川佳宏,和栗雅子,荒田 尚子
    • Organizer
      第59回日本糖尿病学会年次集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 産直後に非糖尿病型であった妊娠糖尿病既往女性のその後の糖尿病発症予測因子について2015

    • Author(s)
      川﨑麻紀、荒田尚子、佐藤志織、釘島ゆかり、坂本なほ子、小川佳宏、宮越敬、和栗雅子、安日一郎
    • Organizer
      第31回日本糖尿病・妊娠学会年時学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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