Elucidation of adiponectin expression pathway based on the co-expression network and epigenome data analysis
Project/Area Number |
15K19242
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hygiene and public health
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Research Institution | Nagoya University |
Principal Investigator |
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Research Collaborator |
YOKOTA Mitsuhiro 愛知学院大学, 歯学部, 教授 (50201851)
MATSUBARA Tatsuaki 愛知学院大学, 歯学部, 教授 (30209598)
ICHIHARA Sahoko 自治医科大学, 医学部, 教授 (20378326)
YAMAMOTO Ken 久留米大学, 医学部, 教授 (60274528)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | エピゲノム / レジスチン / アディポネクチン / バイオインフォマティクス / DNAメチル化 / SNP / 生活習慣病 / 心筋梗塞 |
Outline of Final Research Achievements |
Abnormal secretion of adiponectin is deeply involved in the development of lifestyle disease. The blood concentration is known to be affected by the genetic factors. However, the variance of the concentration explained by genes previously identified as associated genes with concentrations is very low. In this study, we explored DNA methylation sites associated with the adiponectin based on a gene co-expression network analysis and an integration analysis with DNA methylation level using the data for 191 nondiabetic men from a general population and public available data sets. As a result, we identified three sites for both adiponectin level and the expression level of ADIPOQ gene. One site of them was located near a gene, which regulate of ADIPOQ. These results suggest new insights into the regulation of adiponectin via effects on epigenetics.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites.2015
Author(s)
M. Nakatochi, S. Ichihara, K. Yamamoto, K. Ohnaka, Y. Kato, S. Yokota, A. Hirashiki, K. Naruse, H, Asano, H. Izawa, T. Matsubara, and M. Yokota
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Journal Title
Diabetologia
Volume: 58
Issue: 12
Pages: 2781-2190
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] エピゲノムワイド関連研究と一塩基多型(SNP)の統合解析による血漿レジスチン濃度調節機構の解明2016
Author(s)
中杤昌弘, 市原佐保子, 山本健, 大中佳三, 加藤洋介, 横田成紀, 平敷安希博, 成瀬桂子, 浅野展行, 井澤英夫, 松原達昭, 横田充弘
Organizer
第26回日本疫学会学術総会
Place of Presentation
米子コンベンションセンターBigShip(鳥取県米子市)
Year and Date
2016-01-21
Related Report
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[Presentation] Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighboring sites2015
Author(s)
Nakatochi M, Ichihara S, Yamamoto K, Ohnaka K, Kato Y, Yokota S, Hirashiki A, Naruse K, Asano H, Izawa H, Matsubara T, Yokota M
Organizer
ASHG 2015
Place of Presentation
Baltimore, USA
Year and Date
2015-10-06
Related Report
Int'l Joint Research