Moyamoya disease mouse model establishment using Rnf213 mutant transgenic mouse
Project/Area Number |
15K19243
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hygiene and public health
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Research Institution | Chubu University (2017) Kyoto University (2015-2016) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | もやもや病 / RNF213 / ノックアウトマウス / トランスジェニックマウス / Rnf213 |
Outline of Final Research Achievements |
In this study, we used a vascular endothelial-specific Rnf213 mutant Tg mouse and Rnf213 KO mice to create 1) cerebral hypoxia models using hypoxic chamber and 2) cerebral hypoperfusion model by bilateral common carotid artery stenosis (BCAS) method and evaluated cerebral blood vessels. As a result, it was suggested that angiogenesis was impaired in the vascular endothelial-specific Rnf213 mutant Tg mouse, while arteriogenesis was impaired in in Rnf213 KO mice. These results indicate that the cerebral hypoxia/hypoperfusion model may be useful for establishing a mouse model of Moyamoya disease.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion2018
Author(s)
Morimoto T, Enmi J, Hattori Y, Iguchi S, Saito S, Harada K, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
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Journal Title
Sci Rep
Volume: 8
Issue: 1
Pages: 3607-3607
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.2018
Author(s)
Choi J, Kobayashi H, Okuda H, Harada KH, Takeda M, Fujimoto H, Yamane S, Tanaka D, Youssefian S, Inagaki N, Koizumi A.
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Journal Title
PLoS One
Volume: 13 (1)
Issue: 1
Pages: e0190863-e0190863
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease2017
Author(s)
Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada K. H, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
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Journal Title
PLoS ONE
Volume: 12
Issue: 4
Pages: e0175649-e0175649
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] RNF213 rare variants in Slovakian and Czech moyamoya disease patients2016
Author(s)
Hatasu Kobayashi, Miroslav Brozman, Kateina Kyselova, DaaViszlayova, Takaaki Morimoto, Martin Roubec, David koloudik, Andrea Petroviova , Dominik Juskani,Jozef Strauss , Marian Halaj, Peter Kurray , Marian Hranai, Koji Harada, Sumiko Inoue ,Toshiyuki Habu, Roman Herzig , Akio Koizumi
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Journal Title
PLOS ONE
Volume: 11
Issue: 10
Pages: e0164759-e0164759
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] RNF213 is associated with Intracranial Aneurysms in the French-Canadian population.2016
Author(s)
Zhou S, Ambalavanan A, Rochefort D, Xie P, Bourassa CV, Hince P, Dionne-Laporte A, Spiegelman D, Gan-Or Z, Mirarchi C, Zaharieva V, Dupré N, Kobayashi H, Hitomi T, Harada K, Koizumi A, Xiong L, Dion PA, Rouleau GA.
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Journal Title
Am J Hum Genet
Volume: 99(5)
Issue: 5
Pages: 1072-1085
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Infantile pain episodes associated with novel Nav1.9 mutations in familial episodic pain syndrome in Japanese families2016
Author(s)
Hiroko Okuda, Atsuko Noguchi, Hatasu Kobayashi, Daiki Kondo, Kouji H.Harada, Shohab Youssefian, Hirotomo Shioi, Risako kabata, Yuki Domon,Kazufumi Kubota, Yutaka Kitano, Yasunori Takayama, Toshiaki Hitomi,Kousaku Ohno, Yoshiaki Saito, Takeshi Asano, Makoto Tominaga, Tsutomu Takahashi, and Akio Koizumi.
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Journal Title
PLOS ONE
Volume: 11
Issue: 5
Pages: e0154827-e0154827
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics.2016
Author(s)
Harada KH, Tanaka K, Sakamoto H, Imanaka M, Niisoe T, Hitomi T, Kobayashi H, Okuda H, Inoue S, Kusakawa K, Oshima M, Watanabe K, Yasojima M, Takasuga T, Koizumi A.
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Journal Title
PLoS One.
Volume: 11(1)
Issue: 1
Pages: e0146335-e0146335
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.2015
Author(s)
Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, Imai H, Sone M, Taura D, Harada KH, Habu T, Takagi Y, Miyamoto S, Koizumi A.
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Journal Title
J Am Heart Assoc.
Volume: 30;4(7)
Issue: 7
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka2015
Author(s)
Nanayakkara S, Senevirathna S, Parahitiyawa NB, Abeysekera T, Chandrajith R, Ratnatunga N, Hitomi T, Kobayashi H, Harada KH, Koizumi A
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Journal Title
Environ Health Prev Med.
Volume: 20(5)
Issue: 5
Pages: 354-9
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Perfluorinated carboxylic acids discharged from the Yodo River Basin, Japan.2015
Author(s)
Niisoe T, Senevirathna ST, Harada KH, Fujii Y, Hitomi T, Kobayashi H, Yan J, Zhao C, Oshima M, Koizumi A.
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Journal Title
Chemosphere.
Volume: 138
Pages: 81-8
Related Report
Peer Reviewed
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[Presentation] The Prevalence of RNF213 p.R4810K Variant is High in Juvenile-Onset Stroke Patients With Intracranial Arterial Stenosis2018
Author(s)
Teppei Kamimura, Shuhei Okazaki, Takaaki Morimoto, Hatasu Kobayashi, Kouji Harada, Tsutomu Tomita, Aya Higashiyama, Jun C Takahashi, Jyoji Nakagawara, Kazunori Toyoda, Akio Koizumi, Masafumi Ihara
Organizer
International Stroke Conference 2018
Related Report
Int'l Joint Research
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[Presentation] Moyamoya Disease Susceptibility Gene, RNF213 p.R4810K Variant, is a Common Risk Factor for Atherothrombotic Brain Infarction in a Japanese Population2018
Author(s)
Shuhei Okazaki, Takaaki Morimoto, Teppei Kamimura, Hatasu Kobayashi, Kouji Harada, Tsutomu Tomita, Aya Higashiyama, Jun C Takahashi, Jyoji Nakagawara, Kazunori Toyoda, Akio Koizumi and Masafuji Ihara
Organizer
International Stroke Conference 2018
Related Report
Int'l Joint Research
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[Presentation] A Case of Pulmonary Arterial Hypertension with Rare Variant in Moyamoya disease susceptibility gene RNF2132018
Author(s)
Hideyuki Kinoshita, Hatasu Kobayashi, Risako Kabata, Takaaki Morimoto, Midori Takeda, Jungmi Choi, Hiroko Okuda, Kouji H Harada, Shohab Youssefian, Yasuaki Nakagawa, Koichiro Kuwahara Koh Ono, Akio Koizumi, Takeshi Kimura,
Organizer
第82回日本循環器学会学術集会
Related Report
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