| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, we used a vascular endothelial-specific Rnf213 mutant Tg mouse and Rnf213 KO mice to create 1) cerebral hypoxia models using hypoxic chamber and 2) cerebral hypoperfusion model by bilateral common carotid artery stenosis (BCAS) method and evaluated cerebral blood vessels. As a result, it was suggested that angiogenesis was impaired in the vascular endothelial-specific Rnf213 mutant Tg mouse, while arteriogenesis was impaired in in Rnf213 KO mice. These results indicate that the cerebral hypoxia/hypoperfusion model may be useful for establishing a mouse model of Moyamoya disease.
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