Physiological effects of brominated flame retardants on allergic disease, study for prevention

Research Project

Project/Area Number	15K19251
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hygiene and public health
Research Institution	Kyoto University (2016-2017) International University of Health and Welfare (2015)
Principal Investigator	Tanaka Michitaka 京都大学, 工学研究科, 特定研究員 (80647264)
Research Collaborator	Inoue Ken-ichiro 静岡県立大学, 看護学部, 教授 (20373219) Takano Hirohisa 京都大学, 工学(系)研究科, 教授 (60281698)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	アレルギー / 臭素系難燃剤 / 微量曝露 / アトピー性皮膚炎 / 皮膚炎モデルマウス / サイトカイン / 臭素化難燃剤
Outline of Final Research Achievements	Brominated flame retardants (BFRs) are used as additive or reactive components in various materials. Regarding their health concerns, their immunotoxicity have not been clarified yet. In the current study, we examined the effects of systemic exposure to two types of BFRs, DE71 and DE79, on pathophysiologic traits of murine atopic dermatitis (AD). Male NC/Nga mice were repeatedly injected intraperitoneally with DE71 and DE79 and/or mite allergen into their right ears. Thereafter, clinical scores (macroscopic findings of inflammatory foci), Ig values in serum and allergy-related protein in extract were examined. Both DEs significantly aggravated clinical scores induced by mite allergen including skin dryness and edema. Total IgE titer was significantly greater in the Dp + DE79 group than in the Dp group. Taken together, exposure to BFRs can exacerbate AD-like skin lesions related to mite allergen in mice. Particularly, it was shown that worsen atopic dermatitis wear early stage.