Carcinogenicity and species differences by indium compounds exposure.

Research Project

Project/Area Number	15K19252
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hygiene and public health
Research Institution	Keio University
Principal Investigator	Yoshioka Noriyuki 慶應義塾大学, 医学部(信濃町), 助教 (70365229)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	インジウム
Outline of Final Research Achievements	The aim of this study was to assess the mechanism of carcinogenesis and those species differences of indium tin oxide (ITO). ITO, indium oxide and indium hydroxide was exposed to mouse, rat and human macrophage cell lines, respectively. Rat cell lines with highest phagocytic ability in these cell lines were most susceptible to cytotoxicity tests. This observation suggest that phagocytosis was involved in the development of cytotoxicity of indium compounds. Further, exposure to indium oxide induced high levels of reactive oxygen species generation and DNA damage in comparison to ITO and indium hydroxide. It is need to further studies the toxicity of indium oxide in addition to ITO.

Report

(3 results)