| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We investigated the effect of antibiotics on horizontal plasmid transduction using ESBL/AmpC producing E. coli were isolated from meats and fish and shellfish in Vietnam. As a result of the study, it was shown that the number of colonies of the transconjugants can be increased by adding a certain concentration at the time of conjugation in tetracycline and ciprofloxacin. Next, studies on the colistin resistance gene of ESBL / AmpC producing E. coli 261 strains revealed that 62 strains have plasmid harboring mcr-1 or mcr-3 and that plasmids are propagated by horizontal transmission. In addition, genetic analysis was performed on the plasmid having the mcr gene and its details were clarified.
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