| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Outline of Final Research Achievements |
This study investigated the short-term effects of both lipid peroxidation and inflammatory responses on rhabdomyolysis-induced acute kidney injury (AKI). Rhabdomyolysis was induced by glycerol in saline into the rats. Time-dependent increases in serum biochemical parameters were observed 1 hour after glycerol injection. In kidneys, glycerol injection resulted in histopathological changes. We found an increases in lipid peroxidation-mediated oxidative and nitrosative stress within a few hours after glycerol injection and a release of pro-inflammatory cytokines.
Our findings suggest that pro-inflammatory cytokine-mediated inflammatory response might lead to rhabdomyolysis-induced AKI during the very first few hours after glycerol injection, and lipid peroxidation-mediated oxidant injury could promote the development of associated pathophysiological processes.
|
