Exacerbating effects of insulin resistance on Alzheimer's disease
Project/Area Number |
15K19279
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Chiba University |
Principal Investigator |
Izuo Naotaka 千葉大学, 大学院医学研究院, 日本学術振興会特別研究員(PD) (50722261)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | アルツハイマー病 / 糖尿病 / インスリン抵抗性 / 行動解析 / 行動試験 / オメガ3脂肪酸 / メタボリックシンドローム / アミロイドベータ |
Outline of Final Research Achievements |
Insulin resistance is one of risk factors of Alzheimer’s disease (AD). I investigated an exacerbating effects of insulin resistance on AD by phenotypic analyses on model mice. By crossbreeding of insulin resistant mice knocked in mutant insulin receptor and AD model mice, we generated insulin resistant AD model mice. This double knockin mice exhibited deficit of long term memory, decreased anxiety sensitivity and depression in behavioral analyses without affecting senile plaque pathology. By oral administration of Omega-3 fatty acids, insulin resistant AD model mice recovered from psychological symptoms, especially depression. These results would contribute to developing preventive and therapeutic strategies on AD.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis2016
Author(s)
Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
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Journal Title
Sci. Rep.
Volume: 6
Issue: 1
Pages: 29038-29038
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Brain-specific superoxide dismutase 2 deficiency causes perinatal death with spongiform encephalopathy in mice.2015
Author(s)
Izuo, N., Nojiri, H., Uchiyama, S., Noda, Y., Kawakami, S., Kojima, S., Sasaki, T., Shirasawa, T., Shimizu, T.
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Journal Title
Oxid. Med. Cell. Longev.
Volume: 2015
Pages: 238914-238914
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] アミロイド β の毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用2016
Author(s)
村上一馬, 徳田真樹, 鈴木天志, 入江由美, 花木瑞穂, 柳田 亮, 物部容子, 赤木謙一, 石井亮太郎, 建部 陽嗣, 徳田隆彦, 前田雅弘, 久米利明, 泉尾直孝, 清水孝彦, 入江一浩
Organizer
日本農芸化学大会2016年度大会
Place of Presentation
札幌コンベンションセンター (北海道札幌市)
Year and Date
2016-03-27
Related Report
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[Presentation] Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease2015
Author(s)
Murakami, Kazuma; Hanaki-Sato, Mizuho; Moro, Maria L; Giaccone, Giorgio; Tagliavini, Fabrizio; Akagi, Ken-ichi; Ishii, Ryotaro; Tokuda, Takahiko; Maeda, Masahiro; Izuo, Naotaka; Shimizu, Takahiko; Irie, Kazuhiro
Organizer
International Chemical Congress of Pacific Basin Societies 2015
Place of Presentation
Hawaii Convention Center, ホノルル (アメリカ)
Year and Date
2015-12-15
Related Report
Int'l Joint Research
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