The analysis of conversion mechanism from ageing to tumorigenesis by the metabolic-remodeling of glycolysis.
| Project/Area Number |
15K19283
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kyoto University |
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Principal Investigator |
Mikawa Takumi 京都大学, 医学研究科, 教務補佐員 (90608051)
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| Research Collaborator |
KONDOH Hiroshi 京都大学, 大学院医学研究科, 准教授 (80402890)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 解糖系代謝 / 癌 / PGAM / 解糖系酵素 / 発がん / DNA損傷修復 / 解糖系 / Warburg効果 / ガン / ホスホグリセリン酸ムターゼ |
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| Outline of Final Research Achievements |
One of glycolytic enzyme, phosphoglycerate mutase (PGAM) is expects to do strong-target for the preventive therapy of cancer via metabolic regulation. To investigate in vivo effect of PGAM, we generate two PGAM model mice; one is PGAM transgenic mouse, another is PGAM conditional knockout mouse. These mice did not show glucose intolerance. However, we found that PGAM transgenic mice are susceptible to chemical-induced carcinogenesis. Moreover, we found novel PGAM binding protein and its cooperative-biological effect.
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Report
(3 results)
Research Products
(14 results)
