Investigation of mechanisms of structural bone degeneration using new structural index for trabecular bone and finite element method in patients with type 2 diabetes
| Project/Area Number |
15K19286
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO MASAHIRO 島根大学, 医学部, 講師 (50346392)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 有限要素法 / ２型糖尿病 / 椎体骨折 / 臨床CT画像 / 骨質 / 構造特性 / 材質特性 |
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| Outline of Final Research Achievements |
Patients with type 2 diabetes (T2DM) have an increased risk of fracture despite of their higher bone mineral density compared with non-diabetic subjects, suggesting that bone fragility in T2DM is deteriorated by poor bone quality. A role of microarchitecture, one component of bone quality, on fracture risk in this population is unclear.
Using images obtained from computed tomography for clinical use, bone strength of T2DM was calculated by the established procedure of finite element method giving known value on material property of postmenopausal women which is robuster than T2DM. Comparison of the computed bone strength index of diabetic patients with control subjects, significant difference was not observed. This result suggested that the calculation had been performed with excessive material property which may be capable to compensate deteriorated structural property, indirectly demonstrated that bone material property of T2DM was inferior to that of non-diabetic subjects.
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Report
(4 results)
Research Products
(11 results)
