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Evaluation of oxidative stress and elucidation of pathogenesis in Alzheimer disease by in vivo electron paramagnetic resonance imaging

Research Project

Project/Area Number 15K19288
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionSapporo Medical University

Principal Investigator

Matsumura Akihiro  札幌医科大学, 医学部, 助教 (20464498)

Research Collaborator FUJII Hirotada  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアルツハイマー病 / アミロイドβ / トランスジェニック / 酸化ストレス / ROS / redox status / ミクログリア / ガランタミン
Outline of Final Research Achievements

The purpose of this study is to analyze the mechanism of Alzheimer disease (AD) and apply the result to new therapeutic strategy, by evaluating the change of oxidative stress, cognitive function and histopathology in the brain when therapeutic intervention was given to AD model animals. I used in vivo electron paramagnetic resonance (EPR) imaging in order to evaluate the oxidative stress in the brain of model animals. APPswe/PS1dE9 mice (AD mice) and their littermates (Wild mice) were orally dispensed 5mg/kg of galantamine or distilled water from very early stage (3 months of age) or from early stage (6 months of age) of AD.
The results of behavioral assessment by novel object recognition (NOR) test indicated the improvement in congnitive function. Aβ deposition in the cortex decreased in the galantamine-administered group compared with control group. EPR imaging tend to visualize the less oxidative stress in the galantamine treatment group.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging.2015

    • Author(s)
      Matsumura A, Emoto MC, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H,Yamauchi A, Sato-Akaba H, Fujii HG, Shimohama S.
    • Journal Title

      Free Radic Biol Med.

      Volume: 85 Pages: 165-173

    • DOI

      10.1016/j.freeradbiomed.2015.04.013

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Temporal changes of the marker of microglial activation in APdE9 mice.2016

    • Author(s)
      松村晃寛, 鈴木紘美, 藤倉 舞, 岩原直敏, 真部建郎, 松下隆司, 鈴木秀一郎, 久原 真, 川又 純, 下濱 俊
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] APdE9マウスにおけるミクログリア内のマーカーの発現の経時的推移2015

    • Author(s)
      松村晃寛, 藤倉 舞, 岩原直敏, 真部建郎, 松下隆司, 鈴木秀一郎, 久原 真, 川又 純, 下濱 俊
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森( 青森県青森市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Temporal changes of microglial activatio and alpha7 nAChR in APdE9 mice.2015

    • Author(s)
      松村晃寛, 鈴木紘美, 山内綾乃, 岩原直敏, 松下隆司, 鈴木秀一郎, 久原 真, 川又 純, 高田和幸, 北村佳久, 下濱 俊
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟コンベンションセンター( 朱鷺メッセ)( 新潟県新潟市)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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