| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The purpose of this study is to analyze the mechanism of Alzheimer disease (AD) and apply the result to new therapeutic strategy, by evaluating the change of oxidative stress, cognitive function and histopathology in the brain when therapeutic intervention was given to AD model animals. I used in vivo electron paramagnetic resonance (EPR) imaging in order to evaluate the oxidative stress in the brain of model animals. APPswe/PS1dE9 mice (AD mice) and their littermates (Wild mice) were orally dispensed 5mg/kg of galantamine or distilled water from very early stage (3 months of age) or from early stage (6 months of age) of AD.
The results of behavioral assessment by novel object recognition (NOR) test indicated the improvement in congnitive function. Aβ deposition in the cortex decreased in the galantamine-administered group compared with control group. EPR imaging tend to visualize the less oxidative stress in the galantamine treatment group.
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