Improvement of liver stiffness measured using magnetic resonance elastography after DAAs-based therapy in patients with chronic hepatitis C

Research Project

Project/Area Number	15K19290
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General internal medicine(including psychosomatic medicine)
Research Institution	Yokohama City University
Principal Investigator	Tomeno Wataru 横浜市立大学, 附属病院, 助教 (00644957)
Research Collaborator	SAITO Satoru
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	C型慢性肝炎 / 肝硬度 / MRエラストグラフィ / SVR後発癌 / 超音波エラストグラフィ
Outline of Final Research Achievements	We assessed liver stiffness (LS) using magnetic resonance elastography before and after direct acting antivirals (DAAs)-based therapy in 52 patients with chronic hepatitis C. The median LS measurement (LSM) significantly decreased at end of treatment (3.01 kPa) and 6 months after end of treatment (2.59 kPa) compared with baseline (3.69 kPa)(p<0.001). However, we discovered some cases that the LSM turned worse. In the future, a large-scale and long-term analysis of patients with smaller improvements in LSM could enable patients with a high risk of carcinogenesis after HCV elimination to be identified.

Report

(3 results)