Improvement of liver stiffness measured using magnetic resonance elastography after DAAs-based therapy in patients with chronic hepatitis C
| Project/Area Number |
15K19290
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Yokohama City University |
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Principal Investigator |
Tomeno Wataru 横浜市立大学, 附属病院, 助教 (00644957)
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| Research Collaborator |
SAITO Satoru
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | C型慢性肝炎 / 肝硬度 / MRエラストグラフィ / SVR後発癌 / 超音波エラストグラフィ |
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| Outline of Final Research Achievements |
We assessed liver stiffness (LS) using magnetic resonance elastography before and after direct acting antivirals (DAAs)-based therapy in 52 patients with chronic hepatitis C. The median LS measurement (LSM) significantly decreased at end of treatment (3.01 kPa) and 6 months after end of treatment (2.59 kPa) compared with baseline (3.69 kPa)(p<0.001). However, we discovered some cases that the LSM turned worse. In the future, a large-scale and long-term analysis of patients with smaller improvements in LSM could enable patients with a high risk of carcinogenesis after HCV elimination to be identified.
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Report
(3 results)
Research Products
(2 results)
