| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
We investigated the effects on the graft survival of 148 kinds of Japanese herbal medicines recognized officially by Japanese government in the murine cardiac transplant model. In 2016 to 2017, almost all of herbal medicines were completed. Of 148, Shigyaku-san (TJ-35), Shohangekabukuryo-to (TJ-21), and Rikkunshi-to (TJ-43) were furthermore investigated. Our models given TJ-35 and TJ-21 had the significant prolongation of graft survival and could induce the generation of regulatory T cells. In the next study on the mechanisms of each medicine, our models given Kanzo and the main ingredient, Glycyrrhizic acid, could prolong the allograft survivals. In the study of TJ-43, we showed a mild survival prolongation by the administration after grafting and also the improvement of reduction of food intake, suggesting that TJ-43 had the evidence on the treatment of appetite loss after intestinal ileus. This study was published in Transplant International and Transplantation Proceedings.
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