The development of new treatments using probiotics-derived molecules for intestinal fibrosis based on an analysis of its mechanisms
Project/Area Number |
15K19306
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
Kashima Shin 旭川医科大学, 医学部, 助教 (10548655)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | プロバイオティクス / 消化管線維化 / ポリリン酸 / Ferrichrome / マクロファージ / 菌由来活性物質 / 腸内細菌 |
Outline of Final Research Achievements |
I explored the effective molecules derived from probiotic conditioned-media and identified ferrichrome as a candidate anti-fibrotic molecule. However, ferrichrome did not exhibit an anti-fibrotic function, although it did have a strong anti-tumor function. A bioactive polyphosphate derived from Lactobacillus brevis exhibited an anti-inflammatory function through the regulation of TLR4-IFNα/β-JAK/STAT signaling. I have not identified new materials derived from probiotics in this study but will continue to search for new anti-inflammatory antifibrosis materials derived from effective molecules exhibiting anti-fibrotic activity in probiotic conditioned-media.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] A meta-analysis of efficacy and adverse events of cold vs. hot polypectomy.2016
Author(s)
Fujiya M, Sato H, Ueno N, Sakatani A, Tanaka K, Dokoshi T, Fujibayashi S, Nomura Y, Kashima S, Gotoh T, Sasajima J, Moriichi K, Watari J, Kohgo Y.
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Journal Title
World Journal of Gastroenterology
Volume: 21
Issue: 23
Pages: 5436-44
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis.2015
Author(s)
Moriichi K, Fujiya M, Ijiri M, Tanaka K, Sakatani A, Dokoshi T, Fujibayashi S, Ando K, Nomura Y, Ueno N, Kashima S, Gotoh T, Sasajima J, Inaba Y, Ito T, Tanabe H, Saitoh Y, Kohgo Y.
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Journal Title
Int J Colorectal Dis.
Volume: 30
Issue: 12
Pages: 1639-1643
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Bamboo Joint-Like Appearance is a Characteristic Finding in the Upper Gastrointestinal Tract of Crohn's Disease Patients: A Case-Control Study.2015
Author(s)
Fujiya M, Sakatani A, Dokoshi T, Tanaka K, Ando K, Ueno N, Gotoh T, Kashima S, Tominaga M, Inaba Y, Ito T, Moriichi K, Tanabe H, Ikuta K, Ohtake T, Yokota K, Watari J, Saitoh Y, Kohgo Y.
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Journal Title
medicine
Volume: 94
Issue: 37
Pages: e1500-e1500
DOI
Related Report
Peer Reviewed / Open Access
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