The measurement of acetaldehyde in human esophageal tissue by using a novel recirculating device

• Project/Area Number: 15K19308
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: Hatta Waku 東北大学, 大学病院, 医員 (30706932)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: acetaldehyde / アセトアルデヒド / 食道組織内還流装置

Outline of Final Research Achievements

We developed a prototype of a recirculating device for measuring acetaldehyde in esophageal tissue, and then we measured the in vivo acetaldehyde concentration rate of esophageal tissue by using living porcine model. However, we could not measure this rate because it is difficult to keep a recirculating needle into the esophageal epithelium due to interference between the tube of this device and endoscope which was used for entering the recirculating needle into the esophageal epithelium.
However, we revealed that it is possible to measure acetaldehyde concentration rate of esophageal and gastric tissue by endoscopic biopsy, and acquired the preliminary data for the future trial.