Analysis of niche forming factors (paneth cells) for colon cancer stem cells.

• Project/Area Number: 15K19309
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: KUROHA MASATAKE 東北大学, 大学病院, 特任助手 (70709469)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 大腸癌 / 幹細胞 / 大腸癌幹細胞

Outline of Final Research Achievements

Intestinal stem cells have the ability for both permanental self-renewal and differentiation into four types of intestinal epithelial cells. The intestinal stem cells play an important role in maintaining the intestinal homeostasis. However the presence of niche forming factors in colon cancer/adenoma stem cells was not clear. Here, we present that niche forming factors are also necessary for survival of colon cancer/adenoma stem cells and the possibility that EVs(Extracellular vesicles ) secreted from stem cells are involved in niche formation.