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The role of exosome in the crosstalk between cancer cells and fibroblast

Research Project

Project/Area Number 15K19326
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

Hayashi Yoshito  大阪大学, 医学系研究科, 助教 (80647123)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌関連線維芽細胞 / 癌微小環境
Outline of Final Research Achievements

The present study aimed to reveal the mechanism of the activation of fibrobaslts by cancer cells and the role of cancer-derived exosomes as the communication tool between cancer cells and fibroblasts. We studied the effect of co-existence of cancer cells and fibroblasts using cell lines and nude mice. It is indicated that p53 deficiency played a pivotal role in activation of fibroblast to produce VEGF via ROS production, resulting in tumor progression. We detected the microRNAs in the cancer-derived exosome which activated fibroblasts. These raise the possibility of the cancer-drived exosome as the novel therapeutic target or the useful biomarker.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth.2016

    • Author(s)
      Hayashi Y, Tsujii M, Kodama T, Akasaka T, Kondo J, Hikita H, Inoue T, Tsujii Y, Maekawa A, Yoshii S, Shinzaki S, Watabe K, Tomita Y, Inoue M, Tatsumi T, Iijima H, Takehara T.
    • Journal Title

      Carcinogenesis.

      Volume: 37 Issue: 10 Pages: 972-984

    • DOI

      10.1093/carcin/bgw085

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Exosomes derived from colon cancer cells promote tumor progression via the activation of fibroblasts in tumor microenvironment.2017

    • Author(s)
      Yoshito Hayashi, Shunsuke Yoshii, Yoshiki Tsujii, Takanori Inoue, Keiichi Kimura, Akihiko Sakatani, Kengo Nagai, Tetsuji Fujinaga, Satoshi Hiyama, Shinichiro Shinzaki, Kenji Watabe, Hideki Iijima, Tetsuo Takehara
    • Organizer
      Digestive Disease Week 2017
    • Place of Presentation
      Chicago
    • Year and Date
      2017-05-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IL-11 from fibroblasts enhances tumor progression in colon cancer microenvironment2016

    • Author(s)
      Yoshito Hayashi, Takanori Inoue, Keiichi Kimura, Hayato Hikita, Minoru Shigekawa, Ryotaro Sakamori, Tomohide Tatsumi, and Tetsuo Takehara
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] p53機能欠損大腸癌の癌微小環境におけるVEGFの役割2016

    • Author(s)
      林義人、辻井正彦、竹原徹郎
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] p53機能不全大腸癌の癌微小環境におけるVEGFの役割2016

    • Author(s)
      林義人、辻井正彦、竹原徹郎
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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