| Project/Area Number |
15K19327
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 十二指腸乳頭括約筋機能不全 / 乳頭括約筋圧測定 / 内視鏡治療 / SOD / 乳頭圧測定 / 内視鏡的診断法 / 治療効果 |
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| Outline of Final Research Achievements |
Sphincter of Oddi dysfunction (SOD) is a painful syndrome attributed to functional abnormalities or structural alterations of the sphincter of Vater’s papilla. Sphincter of Oddi manometry (SOM) is recognized as the standard diagnostic modality for SOD. However, SOM is not commonly performed because of its technical difficulty and the high incidence of post-procedural pancreatitis. To diminish post-procedural pancreatitis, we developed a new method of SOM. We performed SOM using the guide-wire-type manometer on 12 SOD cases and other cases and also evaluate the short-term and long-term treatment outcomes.The amplitude, frequency of SO contractions were significantly larger in the SOD cases than in other diseases. All SOD patients had favorable short-term treatment responses. However, 2 patients had relapse after the endoscopic treatment during long-term follow up.
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