The role of BAFF in progression of hepatocellular carcinoma

• Project/Area Number: 15K19334
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: Koizumi Mitsuhito 愛媛大学, 医学部附属病院, 講師(病院教員) (40748307)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肝細胞癌 / ANP32B / BAFF

Outline of Final Research Achievements

Originally we aimed to identify the role of B cell activation factor belonging to the tumor necrosis factor family (BAFF) and its physiological significance in hepatocellular carcinoma (HCC). Using BAFF expression attenuated liver cancer cell lines, we failed to show significant features that may explain physiological alteration in HCC. During our above mentioned research, we encountered to a protein, Acidic Nuclear Phosphoprotein 32 Family Member B (ANP32B), which may contribute to the pathogenesis of HCC. Therefore, we investigated the role of ANP32B in HCC. ANP32B was expressed in human HCC tissue and low levels of ANP32B were correlated with poor prognosis. Down-regulation of ANP32B plays a role in the suppression of apoptosis and contributes to the progression of cancer.

Research Products

• [Journal Article] Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma (2017)
  • Author(s): Yoshinori Ohno, Mitsuhito Koizumi, Hironao Nakayama, Takao Watanabe, Yoshio Tokumoto, Taira Kuroda, Masanori Abe, Shinji Fukuda, Shigeki Higashiyama, Teru Kumagi, Yoichi Hiasa.
  • Journal Title: PLOS ONE Volume: 掲載待ち
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study. (2015)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 2 Pages: 230-237
  • DOI: 10.1007/s00535-014-0959-6
  • Peer Reviewed / Open Access
• [Journal Article] Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion. (2014)
  • Author(s): Kuroda T, Hirooka M, Koizumi M, Ochi H, Hisano Y, Bando K, Matsuura B, Kumagi T, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: Epub Issue: 6 Pages: 583-9
  • DOI: 10.1007/s00535-014-1001-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Down-regulated acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) has a role in suppression of apoptosis, and is associated with poor prognosis in patients with hepatocellular carcinoma (2016)
  • Author(s): Yoshinori Ohno, Mitsuhito Koizumi, Hironao Nakayama, Takao Watanabe, Masashi Hirooka, Yohei Koizumi, Yoshio Tokumoto, Taira Kuroda, Shinji Fukuda, Shigeki Higashiyama, Teru Kumagi, Yoichi Hiasa
  • Organizer: AASLD The Liver Meeting 2016
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-11-11
• [Presentation] 膵癌進展におけるB細胞活性化因子の作用 (2015)
  • Author(s): 小泉光仁、渡辺崇夫、大野芳敬、日浅陽一
  • Organizer: 第19回日本がん分子標的治療学会学術集会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2015-06-10
• [Presentation] 生体肝移植後の胆管狭窄に対する内視鏡的治療の現状と課題 (2015)
  • Author(s): 小泉光仁、熊木天児、日浅陽一
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2015-04-23