| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Originally we aimed to identify the role of B cell activation factor belonging to the tumor necrosis factor family (BAFF) and its physiological significance in hepatocellular carcinoma (HCC). Using BAFF expression attenuated liver cancer cell lines, we failed to show significant features that may explain physiological alteration in HCC. During our above mentioned research, we encountered to a protein, Acidic Nuclear Phosphoprotein 32 Family Member B (ANP32B), which may contribute to the pathogenesis of HCC. Therefore, we investigated the role of ANP32B in HCC. ANP32B was expressed in human HCC tissue and low levels of ANP32B were correlated with poor prognosis. Down-regulation of ANP32B plays a role in the suppression of apoptosis and contributes to the progression of cancer.
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