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The role of BAFF in progression of hepatocellular carcinoma

Research Project

Project/Area Number 15K19334
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionEhime University

Principal Investigator

Koizumi Mitsuhito  愛媛大学, 医学部附属病院, 講師(病院教員) (40748307)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肝細胞癌 / ANP32B / BAFF
Outline of Final Research Achievements

Originally we aimed to identify the role of B cell activation factor belonging to the tumor necrosis factor family (BAFF) and its physiological significance in hepatocellular carcinoma (HCC). Using BAFF expression attenuated liver cancer cell lines, we failed to show significant features that may explain physiological alteration in HCC. During our above mentioned research, we encountered to a protein, Acidic Nuclear Phosphoprotein 32 Family Member B (ANP32B), which may contribute to the pathogenesis of HCC. Therefore, we investigated the role of ANP32B in HCC. ANP32B was expressed in human HCC tissue and low levels of ANP32B were correlated with poor prognosis. Down-regulation of ANP32B plays a role in the suppression of apoptosis and contributes to the progression of cancer.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma2017

    • Author(s)
      Yoshinori Ohno, Mitsuhito Koizumi, Hironao Nakayama, Takao Watanabe, Yoshio Tokumoto, Taira Kuroda, Masanori Abe, Shinji Fukuda, Shigeki Higashiyama, Teru Kumagi, Yoichi Hiasa.
    • Journal Title

      PLOS ONE

      Volume: 掲載待ち

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study.2015

    • Author(s)
      Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
    • Journal Title

      J Gastroenterol

      Volume: 50 Issue: 2 Pages: 230-237

    • DOI

      10.1007/s00535-014-0959-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion.2014

    • Author(s)
      Kuroda T, Hirooka M, Koizumi M, Ochi H, Hisano Y, Bando K, Matsuura B, Kumagi T, Hiasa Y.
    • Journal Title

      J Gastroenterol

      Volume: Epub Issue: 6 Pages: 583-9

    • DOI

      10.1007/s00535-014-1001-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Down-regulated acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) has a role in suppression of apoptosis, and is associated with poor prognosis in patients with hepatocellular carcinoma2016

    • Author(s)
      Yoshinori Ohno, Mitsuhito Koizumi, Hironao Nakayama, Takao Watanabe, Masashi Hirooka, Yohei Koizumi, Yoshio Tokumoto, Taira Kuroda, Shinji Fukuda, Shigeki Higashiyama, Teru Kumagi, Yoichi Hiasa
    • Organizer
      AASLD The Liver Meeting 2016
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵癌進展におけるB細胞活性化因子の作用2015

    • Author(s)
      小泉光仁、渡辺崇夫、大野芳敬、日浅陽一
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 生体肝移植後の胆管狭窄に対する内視鏡的治療の現状と課題2015

    • Author(s)
      小泉光仁、熊木天児、日浅陽一
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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