| Project/Area Number |
15K19335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Japanese Foundation for Cancer Research (2016)
Ehime University (2015) |
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Principal Investigator |
Yamamoto Yasunori 公益財団法人がん研究会, 有明病院 消化器内科, 医員 (20649066)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 非アルコール性脂肪肝炎 / 飽和脂肪酸 / MTTP / CD36 / glycosylated CD36 / 肝線維化 / インスリン抵抗性 / NASH / 食事由来飽和脂肪酸 |
|---|
| Outline of Final Research Achievements |
Background & Aims: Saturated fatty acids (SFAs) such as palmitic acid are an important risk factor for the development of hepatic steatosis, lipotoxicity (hepatocellular death), and hepatocarcinogenesis. Major sources of hepatic SFAs are adipose tissue, de novo lipogenesis in the liver, and diet. Increases in SFA from adipose tissue and de novo lipogenesis have been reported in non-alcoholic steatohepatitis (NASH), but changes in dietary SFA intestinal absorption are unclear. Thus, we aimed to clarify these changes and their role in NASH.
Conclusion: Significantly upregulated absorption of dietary SFA was evident in the jejunum of e-NASH patients. This alteration in absorption of SFA would be associated with the increase of MTTP and FABPs in the jejunum, and resulted to the chylomicronemic response in e-NASH patients. Those change of SFA metabolism might relate to the onset or pathogenesis of the early stages of NASH.
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